Perfusion Transport Enclosure for Viable Engineered Organs
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Solution Overview
Problem
There is a shortage of organs for transplantation and biologically engineered organs (BEOs) face challenges in functional release qualification testing and transportation, requiring advanced systems to stimulate and monitor their function and viability during transport.
Innovation Solution
A system for functional testing and transportation of biologically engineered organs (BEOs) that includes an enclosure, perfusate circuit, pump, heating/cooling system, gas transfer unit, sensors, and controller to perfuse and monitor the organ, ensuring it meets functional requirements before and during transport.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If biologically engineered organs are used to solve organ shortage, then organ availability is improved, but functional release qualification testing and transportation reliability become problematic
Solution Approach 1:
The system performs functional release qualification testing before transportation to ensure the biologically engineered organ is viable. The perfusion system is activated prior to transport to stimulate and assess organ function, ensuring the organ meets functional requirements before being transported to the transplantation site.
Solution Approach 2:
Sensors continuously monitor organ function parameters during perfusion and transportation, providing real-time feedback to the control system. This feedback mechanism allows dynamic adjustment of perfusion conditions to maintain organ viability and detect functional issues before they compromise transplantation success.
2Measurement precision
If advanced testing systems are implemented for BEOs, then functional monitoring is improved, but device complexity increases
Solution Approach 1:
The perfusion system is designed to perform multiple functions: it can stimulate organ function, monitor physiological parameters, transport the organ, and provide therapeutic perfusion. By combining these functions into a single integrated system, the patent reduces overall complexity while maintaining comprehensive monitoring capabilities.
Solution Approach 2:
The system includes self-diagnostic capabilities where sensors monitor organ function and the control system automatically adjusts perfusion parameters to maintain optimal conditions. This self-regulating mechanism reduces the need for complex external monitoring equipment and manual interventions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system actively monitors and maintains the health of BEOs, ensuring they meet in-vivo function specifications, reducing the risk of damage and enhancing the reliability of organ transplantation.
Implementation Method 1
a pump for circulating perfusate through the perfusion circuit
Implementation Method 2
an oxygenator
Implementation Method 3
heating/cooling system
Implementation Method 4
heating/cooling system
Data Source
Figure 1
Figure 2
Figure 3A~3B
AI summary
A system (200) for testing and transporting a biologically engineered organ (50) ready for transplant includes a housing (204), a transportable enclosure (202), a perfusate circuit (206), and a pump (208). The housing is configured to receive and support a biologically engineered organ therein in a perfusate flow, and includes a perfusate inlet and a perfusate outlet. The perfusate circuit is connected to the perfusate inlet and the perfusate outlet to transmit perfusate through the system, wherein the pump is configured to circulate perfusate through the perfusate circuit. The system further comprises a gas transfer unit (212) to transfer gas to and from the perfusate, such as oxygen and carbon dioxide, a glucose sensor (224) to produce a glucose sensor signal based on a glucose level of the perfusate, and a controller (216) configured to operate the pump and the gas transfer unit based on the glucose signal. The system may provide further sensors, a heating and cooling system, a sampling port and a dosing port.