Periodic Metal Substrate for Surface Enhanced Raman Scattering
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Solution Overview
Problem
Current methods for measuring biogenic substance concentrations, such as glucose in the body, face challenges in achieving accurate and specific detection due to interference from other substances and light absorption, which affects the reliability and precision of Raman spectroscopy measurements.
Innovation Solution
A method utilizing a substrate with periodic metal structures arranged at specific distances to generate surface enhanced Raman scattering, where the first distance is set to match the phase of the light source and the second distance is between 300 nm and 350 nm, enhancing the electric field and improving measurement accuracy by increasing the intensity of Raman scattering.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional Raman spectroscopy is used to measure biogenic substance concentration, then the measurement can be performed without consumables, but the measurement accuracy is reduced due to interference from other substances and light absorption
Solution Approach 1:
The patent changes the physical parameter of the substrate by introducing periodic metal structures with specific geometries and arrangements. These structures modify the electromagnetic field distribution to enhance Raman scattering signal intensity, thereby improving measurement accuracy despite the presence of interfering substances
Solution Approach 2:
The patent employs a composite substrate combining metal periodic structures with dielectric materials. This composite structure generates surface plasmon resonance that significantly enhances the Raman scattering signal, enabling accurate detection of biogenic substances even in complex biological matrices with interfering components
2Reliability
If surface enhanced Raman scattering is used with metal nanoparticles, then the detection specificity is improved, but the device complexity increases due to precise arrangement requirements
Solution Approach 1:
The patent segments the metal substrate into periodic structures consisting of discrete elements arranged in regular patterns. This segmentation approach simplifies the fabrication process while maintaining the surface plasmon resonance effect, reducing device complexity compared to random nanoparticle arrangements
Solution Approach 2:
The periodic metal structure serves multiple functions: it generates surface plasmon resonance for signal enhancement, provides a regular pattern for simplified fabrication, and creates a uniform electromagnetic field distribution. This multi-functionality reduces overall device complexity while maintaining high detection specificity
Data Source
AI summary
A method for measuring a concentration of a biogenic substance in a living body includes steps of: preparing an apparatus including a light source, a substrate which has periodic metal structures and generates surface enhanced Raman scattering light by being irradiated with light from the light source, and spectroscopic means which disperses and detects the light, wherein the periodic metal structure is arranged with first and second distances in first and second direction respectively, the first distance is set to generate surface plasmon by matching a phase of the light from the light source, and the second distance is smaller than the first distance and is set between 300 nm and 350 nm; irradiating the substrate with the light from the light source to generate the surface enhanced Raman scattering; detecting the scattering with the spectroscopic means; and calculating the concentration of the biogenic substance based on the scattering.