Peripheral Occlusion Device Delivery for Targeted Secondary Treatment
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Solution Overview
Problem
Existing therapeutic agents are systemically distributed through the body, leading to suboptimal concentrations at the target site and accumulation in healthy tissue, necessitating improved targeted drug delivery methods.
Innovation Solution
Peripheral occlusion devices are delivered over-the-wire, utilizing natural hemodynamic forces for focal and stable occlusions, with a single delivery system capable of delivering both the occlusion device and therapeutic agent, and an inner body serving as a working channel for medical devices like steerable ablation needles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If therapeutic agents are delivered systemically through blood circulation, then the therapeutic agent reaches the target site, but suboptimal concentrations are achieved and accumulation occurs in healthy tissue
Solution Approach 1:
An occlusion device is deployed at the target site before delivering the therapeutic agent. This preliminary occlusion action prevents the agent from flowing downstream to healthy tissue, ensuring concentrated delivery only at the intended target site while preventing harmful accumulation elsewhere
Solution Approach 2:
The therapeutic agent is delivered locally at the target site through the delivery system's distal opening rather than systemically. The occlusion device creates a localized treatment zone, concentrating the agent precisely where needed and preventing systemic distribution to healthy tissues
2Device complexity
If a single delivery system is used to deliver both occlusion device and therapeutic agent, then device complexity is reduced, but the system must perform multiple functions
Solution Approach 1:
The delivery system is designed with multi-functionality, serving both as an occlusion device delivery mechanism and a therapeutic agent delivery system. The single system includes an outer body for occlusion device delivery, an inner body for agent delivery, and a working channel for additional instruments, eliminating the need for separate delivery systems
Solution Approach 2:
The delivery system merges multiple functions into a single integrated device: the outer body delivers the occlusion device, the inner body delivers the therapeutic agent, and the working channel accommodates additional medical instruments. This consolidation reduces overall system complexity while maintaining full functional capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances targeted delivery of therapeutic agents to the site while preventing reflux and accumulation in healthy tissue, allowing for precise delivery and secondary treatments using a common delivery system.
Implementation Method 1
Such occlusion devices take advantage of natural hemodynamic forces to provide immediate, focal, and stable occlusions
Data Source
AI summary
Methods of using a common delivery system to deliver an embolization device and provide a secondary treatment. The secondary treatment may include delivering a therapeutic agent or providing a treatment using a treatment instrument. The secondary treatment may be provided downstream of the embolization device. The secondary treatment may be provided using the inner body of the delivery system, while the inner body extends through the opening of the occlusion device.