Peristaltic Pump Linear Range Dosing for Medical Preparations

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Solution Overview

Problem

Existing systems for producing medicinal preparations for parenteral nutrition face challenges in accurately dosing both large and micro-amount components due to the non-linear characteristic curve of peristaltic pumps, which affects dosing accuracy and precision.

Innovation Solution

The method involves positioning the peristaltic pump to operate exclusively within its linear characteristic range for precise dosing of micro-amounts and using a universal liquid to calibrate and ensure accurate delivery, while allowing the pump to operate in both linear and non-linear ranges for main components, with real-time weight checks and flow rate monitoring to verify dosing accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a peristaltic pump operates in its non-linear characteristic range, then it can handle both large and small volumes, but dosing accuracy deteriorates

Engineering Contradiction:
Improveability to handle different volume rangesVSAvoiddosing accuracy
Core Design Contradiction:
Adaptability or versatilityVSManufacturing precision

Solution Approach 1:

The dosing process is segmented into two distinct phases: a positioning phase where the pump operates in non-linear range to quickly deliver large volumes, and a dosing phase where the pump operates in linear range to precisely deliver micro-doses. This segmentation allows the system to leverage the advantages of both operating ranges while avoiding their respective disadvantages

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The pump is pre-positioned in the linear characteristic range before dosing micro-amounts. This preliminary positioning ensures that when the actual dosing occurs, the pump is already operating in the optimal range for precision, eliminating the need to switch ranges during the critical dosing phase

Inventive Principle:
Principle #10Preliminary action

2Manufacturing precision

If the pump operates exclusively in linear range for micro-doses, then dosing precision improves, but production time increases

Engineering Contradiction:
Improvemicro-dose accuracyVSAvoidproduction speed
Core Design Contradiction:
Manufacturing precisionVSProductivity

Solution Approach 1:

The overall dosing process is divided into two segments: a fast positioning segment using non-linear range operation for large volumes, and a precise dosing segment using linear range operation for micro-amounts. This segmentation allows each phase to be optimized for its specific purpose without compromising the other

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The pump alternates between two operational modes: a periodic non-linear operation for rapid volume delivery, followed by a periodic linear operation for precise micro-dosing. This periodic switching between operational ranges optimizes both speed and accuracy throughout the dosing cycle

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables precise and accurate dosing of both large and micro-amounts, enhancing the reliability and safety of medicinal preparations by ensuring accurate composition and minimizing errors, thus meeting stringent safety and accuracy requirements.

Implementation Method 1

a peristaltic pump is used for transferring liquids from source containers to a target container

Methodology Applied
Scientific EffectPeristalsis: Peristalsis

Data Source

PatentEP3429544B1Method for producing a medical preparation using a hose pump
Publication Date: 2023.04.19 FRESENIUS KABI DEUTSCHLAND GMBH
  • EP3429544B1 patent drawingFigure 1
  • EP3429544B1 patent drawingFigure 2
  • EP3429544B1 patent drawingFigure 3

AI summary

The invention relates to a method and a system for synthesizing a medical preparation, a peristaltic pump being used for pumping liquid from a plurality of source containers. According to the invention, micro-amounts are extracted only in the linear region of the peristaltic pump.