Multilayer Peritoneal Membrane Implant for Hernia Repair
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Solution Overview
Problem
Current tissue repair implants face challenges in providing adequate mechanical strength and preventing adhesion formation while promoting native peritoneum regeneration, often requiring alternative biologic tissues and struggling with adhesion issues during wound healing.
Innovation Solution
A tissue repair implant comprising multiple layers of peritoneal membranes, processed to enhance mechanical strength and promote tissue regeneration, with layers that can be non-crosslinked, partially crosslinked, or fully crosslinked to resist or facilitate tissue remodeling, and attached using adhesives or sutures, to prevent adhesion and support wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a single layer of peritoneal membrane is used, then the implant is simpler and easier to manufacture, but the mechanical strength is insufficient
Solution Approach 1:
The peritoneal membrane is divided into multiple separate layers that are stacked and joined together. Each layer maintains its individual structural integrity while contributing to the overall strength of the implant. The layers can be processed and prepared separately before assembly, allowing for quality control and consistent performance of each component.
Solution Approach 2:
The implant combines multiple layers of peritoneal membrane into a composite structure. This composite construction integrates the advantages of each layer, creating a material with enhanced mechanical properties that exceed those of a single layer. The layered composite approach allows for optimization of both strength and biological functionality.
2Stability of the object's composition
If the peritoneal membrane is crosslinked to resist remodeling, then the implant maintains its structural integrity longer, but tissue regeneration is inhibited
Solution Approach 1:
Different regions or layers of the peritoneal membrane implant are subjected to different crosslinking degrees. Some layers are heavily crosslinked to provide structural stability and resistance to remodeling, while other layers remain lightly crosslinked or uncrosslinked to facilitate tissue regeneration and cellular infiltration. This spatial variation in crosslinking density allows simultaneous achievement of both structural integrity and biological functionality.
Solution Approach 2:
The crosslinking parameters (degree, density, distribution) are systematically varied across different layers of the implant. By controlling crosslinking parameters such as glutaraldehyde concentration, exposure time, and temperature, the implant achieves a gradient structure where mechanical stability and regenerative capacity are optimized in different zones according to functional requirements.
3Strength
If alternative biologic tissues are used instead of peritoneal membrane, then mechanical strength may be improved, but adhesion formation increases
Solution Approach 1:
The implant uses multiple layers of the same peritoneal membrane material rather than combining different biologic tissues. This homogeneity ensures that the surface properties remain consistent and biocompatible throughout the implant, preventing adhesion formation while maintaining adequate mechanical strength through the layered construction. The uniform peritoneal membrane surface promotes proper tissue integration without triggering excessive adhesive responses.
Data Source
AI summary
Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples.