Permeable Shell Filamentary Device for Cerebral Aneurysm Occlusion
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Solution Overview
Problem
Current treatments for cerebral aneurysms, such as coil-type vaso-occlusive devices and stents, face limitations including poor packing density, compaction due to hydrodynamic pressure, instability in wide-necked aneurysms, and difficulty in deployment, especially in small and tortuous cerebral blood vessels, necessitating the development of more effective devices for blocking blood flow without significant risk of deformation or dislocation.
Innovation Solution
A self-expanding resilient permeable shell with a woven structure of elongate filaments, configured to expand radially and form a smooth path with openings that slow blood flow below thrombotic threshold velocity, allowing for delivery through microcatheters and anchoring within vascular defects to promote thrombosis and occlusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If coil-type vaso-occlusive devices are used to treat cerebral aneurysms, then blood flow can be blocked, but the devices suffer from poor packing density and compaction due to hydrodynamic pressure
Solution Approach 1:
The patent employs a flexible membrane structure that can be delivered in a compressed state and then expands to form a stable barrier within the aneurysm. This membrane approach replaces traditional coil structures, providing consistent packing density without compaction while maintaining the ability to block blood flow effectively.
Solution Approach 2:
The device transitions from a compressed delivery state to an expanded functional state, allowing it to adapt to the aneurysm geometry. This dynamic transformation enables the membrane to achieve optimal packing density and stability after deployment, overcoming the static limitations of coil structures that are subject to hydrodynamic compaction.
2Ease of operation
If stents are used to treat cerebral aneurysms, then blood flow can be managed, but the devices exhibit instability in wide-necked aneurysms and difficulty in deployment
Solution Approach 1:
The membrane device is nested within a delivery catheter system, allowing for minimally invasive deployment through small access points. The nested configuration enables the device to be delivered to the aneurysm site and then expanded to provide stable support, particularly in wide-necked aneurysms where traditional stents struggle.
Solution Approach 2:
The flexible membrane structure can conform to the complex geometry of wide-necked aneurysms, providing stable support and blood flow management that rigid stent structures cannot achieve. The membrane's flexibility allows it to adapt to varying aneurysm shapes and sizes while maintaining stability.
3Reliability
If devices are designed for minimal deformation, then treatment stability improves, but the complexity of the device structure increases
Solution Approach 1:
The membrane structure provides inherent resistance to deformation through its material properties and geometric configuration, eliminating the need for complex reinforcement structures. This simple yet effective design maintains treatment stability without increasing device complexity.
Solution Approach 2:
The device is divided into functional segments that can be independently optimized for specific performance characteristics. This segmentation allows each portion of the device to contribute to deformation resistance without requiring the entire structure to be overly complex.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively occludes blood flow in cerebral aneurysms, reducing the risk of deformation and compaction, while allowing initial perfusion to facilitate thrombosis and healing, thereby providing a minimally invasive and stable treatment option for cerebral aneurysms.
Implementation Method 1
self-expanding resilient permeable shell
Implementation Method 2
compaction due to hydrodynamic pressure
Implementation Method 3
allowing blood flow through the openings at a velocity below a thrombotic threshold velocity
Data Source
AI summary
Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments may include a permeable shell and inner structure configured to occlude blood flow therethrough.