Antimicrobial Peroxidase Compositions with Enhancing Agents

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Solution Overview

Problem

Current antimicrobial compositions based on peroxidase systems require high concentrations and prolonged incubation for effective antimicrobial activity against bacteria and fungi, and lack non-toxic, water-soluble compounds with prolonged antimicrobial effects suitable for medical applications like wound disinfection.

Innovation Solution

Development of pharmaceutical compositions combining a peroxide or peroxide generating system, a peroxidase, and a water-soluble, moderately hydrophobic substituted benzene or phenol molecule as an enhancing agent, which enhances antimicrobial activity and is suitable for topical use in wound dressings and skin disorders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Power

If aromatic flavouring compounds such as syringaldehyde and vanillin are used as enhancing agents, then peroxidase activity is enhanced, but antimicrobial activity is only observed at high concentrations and after prolonged periods of incubation

Engineering Contradiction:

Improveperoxidase activityVSAvoidincubation period

Core Design Contradiction:

PowerVSLoss of time

Solution Approach 1:

The patent changes the chemical parameters of the enhancing agent by selecting compounds with specific properties: water solubility of at least 0.1% (w/v) and moderate hydrophobicity with log P between 1 and 4. This parameter optimization allows the compounds to effectively enhance peroxidase activity while maintaining rapid antimicrobial action without requiring high concentrations or prolonged incubation periods.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite system combining peroxide (or peroxide generating system), peroxidase enzyme, and specifically selected substituted benzene or phenol compounds as enhancing agents. This composite formulation synergistically enhances peroxidase activity and provides rapid, prolonged antimicrobial effect, resolving the contradiction between enzyme activation and treatment time.

Inventive Principle:

Principle #40Composite materials

2Power

If existing peroxidase enhancing compounds are used, then peroxidase activity is enhanced, but they lack non-toxicity and sufficient water solubility for medical applications

Engineering Contradiction:

Improveperoxidase activityVSAvoidtoxicity

Core Design Contradiction:

PowerVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the chemical parameters of enhancing agents by selecting compounds with moderate hydrophobicity (log P between 1 and 4) and adequate water solubility (at least 0.1% w/v). This parameter selection ensures the compounds are sufficiently water-soluble for medical applications while maintaining low toxicity, unlike previous enhancing agents that required high concentrations and showed toxic effects.

Inventive Principle:

Principle #35Parameter changes

3Power

If existing peroxidase enhancing compounds are used, then peroxidase activity is enhanced, but they lack prolonged antimicrobial effect suitable for medical applications

Engineering Contradiction:

Improveperoxidase activityVSAvoidantimicrobial effect duration

Core Design Contradiction:

PowerVSDuration of action of moving object

Solution Approach 1:

The invention formulates a composite system where peroxide (or peroxide generating system), peroxidase, and specifically selected substituted benzene or phenol compounds work synergistically. This composite formulation provides both rapid initial activity and prolonged antimicrobial effect, making it suitable for medical applications such as wound disinfection where sustained protection is required.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions demonstrate prolonged antimicrobial activity against bacteria and fungi, reducing the need for frequent application and minimizing toxicity, making them suitable for prolonged topical use in medical treatments.

Implementation Method 1

Peroxidase enzymes are used in these applications to convert hydrogen peroxide into radicals

Methodology Applied

Scientific EffectPeroxidase catalysis: Enzyme

Implementation Method 2

Peroxidase enzymes are used in these applications to convert hydrogen peroxide into radicals

Methodology Applied

Scientific EffectOxidation: Oxidation

Implementation Method 3

a certain group of substituted benzene or phenol molecules, which are water soluble and have a moderate hydrophobicity, are especially suitable for enhancing a peroxidase based anti-microbial pharmaceutical composition

Methodology Applied

Scientific EffectHydrophobicity-solubility balance: Hydrophobe

Data Source

PatentUS8679526B2Antimicrobial peroxidase compositions

Publication Date: 2014.03.25 FLEN PHARMA

AI summary

The present invention discloses a class of compounds which have an enhancing effect on peroxidase based antimicrobial compositions. The invention relates to pharmaceutical compositions for prolonged topical use comprising enhancing agents such as methoxyphenols and substituted benzylaldehydes. Examples hereof are respectively guaiacol and vanillin.