Peroxidase Stabilization via Phenoxyethanol in Detergents

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Solution Overview

Problem

Existing detergent and cleaning agent formulations face challenges in stabilizing enzymes, particularly peroxidases, during dilution, which leads to instability and requires expensive dosing systems or addition of solvents like glycerin or propylene glycol to maintain stability.

Innovation Solution

Incorporating phenoxyethanol into the composition with peroxidases, especially in aqueous solutions, significantly enhances enzyme stability, allowing for longer storage and reduced need for precise dosing systems.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If enzymes are diluted in aqueous solutions, then the cleaning agent can be properly formulated and stored, but the enzyme stability decreases over time

Engineering Contradiction:
Improveformulability of cleaning agentVSAvoidenzyme stability
Core Design Contradiction:
Ease of manufactureVSStability of the object's composition

Solution Approach 1:

Phenoxyethanol is introduced as an intermediary substance that mediates between the aqueous environment and the enzyme. It acts as a stabilizing agent that allows the enzyme to remain stable in diluted aqueous solutions, eliminating the need for concentrated enzyme formulations while maintaining enzyme activity over time.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the chemical parameter of the aqueous solution by adding phenoxyethanol, which alters the physical-chemical environment to be more favorable for enzyme stability. This parameter change allows the enzyme to maintain its structural integrity and catalytic activity in diluted conditions.

Inventive Principle:
Principle #35Parameter changes

2Stability of the object's composition

If small volumes of enzyme are dosed precisely, then enzyme stability is maintained, but expensive and sensitive dosing stations are required

Engineering Contradiction:
Improveenzyme stabilityVSAvoiddosing system complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The invention replaces expensive, sensitive dosing equipment with a simpler, more robust system that uses phenoxyethanol-stabilized enzyme formulations. The stabilizing agent allows for less precise but cheaper dosing mechanisms while maintaining enzyme stability, effectively substituting complex equipment with a chemical solution.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

Phenoxyethanol serves as an intermediary that decouples the relationship between dosing precision and enzyme stability. By providing chemical stabilization, it allows standard dosing equipment to achieve adequate results without requiring specialized high-precision dosing stations.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Stability of the object's composition

If solvents like glycerin or propylene glycol are added to diluted enzyme, then enzyme stability is improved, but the formulation becomes more complex and costly

Engineering Contradiction:
Improveenzyme stabilityVSAvoidformulation complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

Phenoxyethanol is presented as a simpler, more cost-effective alternative to traditional enzyme stabilizers like glycerin and propylene glycol. It achieves the same stabilizing effect with a single additive that is easier to work with and less expensive, reducing formulation complexity.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention changes the approach to enzyme stabilization by using phenoxyethanol, which has different physical-chemical properties compared to traditional solvents. This parameter change simplifies the formulation while maintaining or improving enzyme stability.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentEP4098730A1Stabilization of enzymes by phenoxyethanol
Publication Date: 2022.12.07 HENKEL KGAA
  • EP4098730A1 patent drawing
  • EP4098730A1 patent drawing
  • EP4098730A1 patent drawing

AI summary

The invention relates to a composition containing at least one peroxidase and phenoxyethanol. Furthermore, the invention relates to a washing or cleaning agent comprising the composition according to the invention and the use of phenoxyethanol for stabilizing enzymes.