Hydrogen Peroxide-Hyaluronic Acid Composition for Tumor Radiosensitization

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Solution Overview

Problem

Existing radiosensitizers like hydrogen peroxide have irritant properties and are unstable, making them unsafe for direct application and prone to rapid degradation, limiting their effectiveness in treating radioresistant tumors.

Innovation Solution

Combining hydrogen peroxide with hyaluronic acid or its salts to reduce irritation and stabilize the peroxide, allowing safe injection and prolonged efficacy as a radiosensitizer.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hydrogen peroxide is used as a radiosensitizer, then the sensitivity to radiation effect is increased, but irritation to the affected area and instability are caused

Engineering Contradiction:

Improveradiosensitization effectVSAvoidirritation to affected area

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Hyaluronic acid is introduced as an intermediary substance that mediates between hydrogen peroxide and the tumor tissue. It reduces the direct irritation of hydrogen peroxide on the affected area while maintaining the radiosensitization effect, making the treatment safer and more tolerable for patients

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The chemical environment parameters are changed by adding hyaluronic acid, which modifies the stability and reactivity characteristics of hydrogen peroxide in the tumor microenvironment, reducing its harmful effects while preserving therapeutic benefits

Inventive Principle:

Principle #35Parameter changes

2Reliability

If hydrogen peroxide is used to sensitize tumors, then radiation sensitivity is enhanced, but rapid degradation by anti-oxidative enzymes occurs

Engineering Contradiction:

Improveradiation sensitivity enhancementVSAvoidstability of hydrogen peroxide

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

Hyaluronic acid acts as a protective intermediary that shields hydrogen peroxide from rapid degradation by anti-oxidative enzymes in the tumor microenvironment, extending its duration of action and maintaining effective concentrations for a longer period

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The combination with hyaluronic acid provides beforehand cushioning protection against the degrading action of anti-oxidative enzymes, preventing rapid breakdown of hydrogen peroxide before it can exert its radiosensitizing effect

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Adaptability or versatility

If linear accelerator-based radiotherapy is used, then treatment accessibility is improved, but effectiveness on radioresistant tumors is reduced

Engineering Contradiction:

Improvetreatment accessibilityVSAvoideffectiveness on radioresistant tumors

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

H2O2-hyaluronic acid combination acts as a chemical intermediary that enhances the biological effectiveness of linear accelerator-based radiotherapy on radioresistant tumors, bridging the gap between accessible treatment modality and therapeutic efficacy

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The biological parameters of tumor cell sensitivity are changed by the H2O2-hyaluronic acid combination, converting radioresistant cells into radio-sensitive cells, thereby maintaining effectiveness with conventional linear accelerator therapy

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination enhances radiosensitization effects on radioresistant tumors by reducing irritation and degradation, improving treatment outcomes for radiotherapy and chemotherapy.

Implementation Method 1

One cause that can be cited for the radiation resistance of osteosarcoma cells is the presence of anti-oxidative enzyme (peroxidase, catalase) in the cells. Hydrogen peroxide is thought to block the action of the anti-oxidative enzyme.

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Implementation Method 2

when irradiation is conducted in the presence of hydrogen peroxide, the action of the anti-oxidative enzyme is blocked and oxygen is produced, oxidizing the radioresistant hypoxic cells, thereby converting them to being highly sensitive to radiation

Methodology Applied

Scientific EffectOxidation: Oxidation

Implementation Method 3

when irradiated in the presence of a low concentration (0.1 mM, for example) of hydrogen peroxide, reactive oxygen species can be clearly produced in cells exposed to radiation in the order of 10 Gy, giving rise to apoptosis

Methodology Applied

Scientific EffectRadiation-induced oxidative stress: Radiation

Data Source

PatentUS12616650B2Radiation sensitizer of anti-cancer chemotherapy sensitizer

Publication Date: 2026.05.05 OGAWA YASUHIRO

AI summary

The present invention provides a radiosensitizer or anti-cancer chemotherapy sensitizer including a combination of (a) hydrogen peroxide and (b) hyaluronic acid or a salt thereof, wherein the hydrogen peroxide content in a final formulation is 0.1 to 3.5 weight percent.