Persistent Hand Sanitizer Composition for Continuous Antimicrobial Protection
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Solution Overview
Problem
Existing hand sanitizers provide temporary protection against microbes and viruses, requiring repeated application throughout the day, which is inconvenient and may not consistently prevent infection.
Innovation Solution
A persistent sanitizer composition comprising a water and oil formulation with a predominance of water, including bioactive compounds such as benzalkonium chloride, zinc oxide nanoparticles, tributyl phosphate, soybean oil, and Triton X-100, which remains active throughout the day after application, providing continuous antimicrobial and antiviral protection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional hand sanitizers are used, then immediate antimicrobial protection is achieved, but the protection is temporary and requires repeated application throughout the day
Solution Approach 1:
The patent formulates a hand sanitizer composition that maintains continuous antimicrobial protection throughout the day through a unique water-and-oil formulation with predominance of water. The composition includes benzalkonium chloride (0.1-0.2%), zinc source (0.01-0.1%), tributyl phosphate (0.08-0.8%), soybean oil (0.64-6.4%), and Triton X-100 (0.08-0.8%), creating a persistent protective film on the skin that does not require repeated application, thereby achieving continuous useful action.
2Reliability
If conventional hand sanitizers with high alcohol content are used, then rapid antimicrobial activity is achieved, but a greasy feel and potential skin irritation occur
Solution Approach 1:
The patent changes the formulation parameters by using a water-and-oil composition with predominance of water instead of traditional high-alcohol formulations. This parameter change maintains reliable antimicrobial effectiveness through benzalkonium chloride and zinc source while eliminating the greasy feel associated with oil-based products and reducing skin irritation potential, thus resolving the contradiction between reliability and harmful factors.
3Reliability
If frequent reapplication of hand sanitizer is performed, then continuous protection is maintained, but user compliance decreases and time is lost
Solution Approach 1:
The patent applies preliminary action by formulating a hand sanitizer that provides long-lasting protection in a single application. The unique composition with benzalkonium chloride, zinc source, tributyl phosphate, soybean oil, and Triton X-100 creates a persistent film that maintains protective action throughout the day, eliminating the need for frequent reapplication and thereby reducing time loss while maintaining reliable continuous protection.
Data Source
AI summary
Provided herein are compositions and related methods related to a class of formulation that can be applied once a day and still provide antimicrobial and/or antiviral protection during this period, thus exhibiting persistent sanitization to the user. In some embodiments, a hand cream with antimicrobial and/or antiviral protection can prevent against COVID-19 spread or infection. In some embodiments, the formulation comprises one or more of the following: benzalkonium chloride, zinc oxide, tributyl phosphate, soybean oil, and/or Triton X-100, or an analog, derivative, salt, or pharmaceutical equivalent thereof, with the formulation containing a predominance of water to prevent a greasy feel to the user.