Personalized Probiotic Formulation for Microbiome Modulation
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Solution Overview
Problem
Current methods for modulating the human microbiome are limited by variability in individual responses, limited efficacy, and potential side effects, and lack targeted and personalized approaches, particularly in characterizing health conditions and therapies.
Innovation Solution
A method involving the administration of a probiotic formulation comprising selected and/or engineered microbial strains to promote a desired microbial community, which includes screening for microorganisms from fecal samples to isolate and test their ability to increase beneficial and decrease pathogenic microorganisms, and administering them via various routes to restore balance to the microbiome.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional probiotic formulations are administered to modulate the microbiome, then some therapeutic effect is achieved, but the response varies significantly between individuals and efficacy is limited
Solution Approach 1:
The patent applies preliminary action by performing comprehensive microbiome characterization and selecting specific microbial strains before administration. The method involves isolating, culturing, and characterizing microorganisms from the patient's own fecal sample, then selecting strains with proven ability to promote beneficial microbial communities. This pre-screening and personalization approach ensures that the probiotic formulation is tailored to each individual's specific microbiome composition, thereby reducing response variability and improving therapeutic efficacy.
2Adaptability or versatility
If broad-spectrum probiotic formulations are used, then multiple microbial functions are covered, but the formulation lacks targeted effectiveness for specific health conditions
Solution Approach 1:
The patent applies local quality by transitioning from uniform, broad-spectrum probiotic formulations to personalized formulations tailored to each individual's specific microbiome composition and health needs. The method involves characterizing the patient's unique microbial community structure, identifying specific beneficial strains, and formulating a probiotic product containing precisely those strains. This personalized approach ensures that each formulation has the specific quality and composition needed to address that particular patient's health condition, rather than using a generic one-size-fits-all approach.
3Measurement precision
If extensive microbiome characterization and personalized probiotic formulation are implemented, then therapeutic precision is improved, but the complexity of the method increases
Solution Approach 1:
The patent applies self-service by utilizing the patient's own microbiome as the source material for the probiotic formulation. The method involves isolating, culturing, and characterizing microorganisms from the patient's own fecal sample, then selecting and formulating strains from that same sample. This self-service approach simplifies the overall process by eliminating the need for complex external strain selection and formulation procedures, while still achieving high precision through personalized characterization of the patient's unique microbial community.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively promotes a healthy gut flora, reduces inflammation, and improves immune function by selecting microbial strains that colonize and produce beneficial metabolites, offering a more targeted and personalized approach to modulating the microbiome for therapeutic benefits.
Implementation Method 1
selecting and/or engineered to produce a desired effect in the microbiome of the individual
Data Source
AI summary
The present disclosure relates to a method of modulating the microbiome in a human subject, comprising administering a probiotic formulation to an individual. In particular, the probiotic formulation comprises one or more microbial strains that have been selected and/or engineered to produce a desired effect in the microbiome of the individual. Further, the probiotic formulation may be administered via a variety of routes, including orally, nasally, and/or rectally