Personalized SLIT Regimens From At-Home Allergen Testing

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Solution Overview

Problem

Traditional allergy treatments, such as antihistamines and subcutaneous immunotherapy, only manage symptoms and require frequent medical visits, while immunotherapy is cumbersome and not personalized.

Innovation Solution

A sublingual immunotherapy (SLIT) framework that uses patient-collected specimens for testing, analyzes IgE levels, and formulates customized treatment regimens based on individual allergen triggers, regional pollination schedules, and cross-reactivity, enabling at-home treatment with minimal human interaction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If subcutaneous immunotherapy (SCIT) is used to treat allergies, then the patient's reaction to allergen is reduced, but the patient requires regular office visits for testing and treatment administration

Engineering Contradiction:

Improveallergy treatment effectivenessVSAvoidtime for regular office visits

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent replaces the mechanical process of subcutaneous injection (SCIT) with a sublingual delivery mechanism. The allergen extract is administered through the mouth (sublingually) rather than through skin injections, eliminating the need for needles and frequent office visits while maintaining immunotherapy effectiveness

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system enables patients to self-administer the immunotherapy treatment at home using the provided sublingual device and allergen extracts. The patient collects their own blood specimen, receives automated analysis, and manages their treatment schedule without requiring regular visits to an allergist, making the treatment self-service oriented

Inventive Principle:

Principle #25Self-service

2Ease of operation

If traditional allergy medication (antihistamines) is used, then allergy symptoms are treated, but the underlying allergy is not addressed and medication must be taken continuously

Engineering Contradiction:

Improvesymptom management convenienceVSAvoidallergy cure effectiveness

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent converts the harmful continuous need for medication into a beneficial one-time treatment. By using sublingual immunotherapy with allergen extracts, the system addresses the underlying allergy cause rather than just suppressing symptoms, converting the chronic medication requirement into a finite treatment course that builds long-term immunity

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The system performs preliminary allergen identification through automated blood testing before initiating treatment. The patient's blood is collected and analyzed to determine specific allergen triggers, allowing the treatment regimen to be customized in advance based on individual allergy profiles rather than using generic medications

Inventive Principle:

Principle #10Preliminary action

3Reliability

If personalized treatment regimens are created based on individual allergen triggers, then treatment efficacy is improved, but the system complexity increases

Engineering Contradiction:

Improveindividualized treatment efficacyVSAvoidsystem complexity for treatment formulation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces complex manual analysis and prescription processes with an automated computer system. The system automatically analyzes blood test results, identifies allergen triggers, determines treatment regimens, and generates prescriptions without requiring manual intervention from allergists for each treatment detail, reducing system complexity while maintaining personalization

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The automated system performs multiple functions within a single integrated platform: blood specimen analysis, allergen identification, treatment regimen determination, prescription generation, and patient education. This multi-functional approach consolidates what would otherwise require multiple separate processes and professionals into one unified system

Inventive Principle:

Principle #6Universality (Multi-functionality)

4Productivity

If sublingual immunotherapy is implemented with automated testing, then the number of office visits is reduced, but the initial testing and setup process becomes more complex

Engineering Contradiction:

Improvetreatment delivery efficiencyVSAvoidinitial testing and setup complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The system performs all necessary testing, analysis, and treatment formulation in advance before the patient begins active treatment. Blood specimens are collected and analyzed beforehand, allergen triggers are identified, and personalized regimens are created prior to treatment initiation, so that the actual treatment delivery phase is simple and requires minimal complexity

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent introduces an automated intermediary system that bridges the patient and the allergist. This digital intermediary handles the complex tasks of blood analysis, allergen identification, and treatment regimen determination, allowing the patient to have a simpler initial experience while the intermediary system manages the complexity of personalized treatment formulation

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS20250356976A1Determining and optimizing individualized treatment regimens

Publication Date: 2025.11.20 NOHO ALLERGY INC

AI summary

A method and system may be provided to identify allergen triggers and formulate custom allergy treatment regimens based on patient information and test results.