Integrated PET-EPR Imaging System for Tumor Microenvironment Analysis
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Solution Overview
Problem
Current PET and EPR imaging modalities operate as standalone systems, preventing temporal and spatial correlation of images, which hinders effective monitoring of complex in vivo environments like tumor microenvironments.
Innovation Solution
A combined PET-EPR system is developed, integrating an EPR resonator with a PET scanner, featuring a ring geometry, gradient coils, magnets, and a subject module for temperature and anesthesia control, allowing simultaneous PET and EPR data collection and image reconstruction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If PET and EPR imaging modalities operate as standalone systems, then each modality can independently measure its specific parameters (PET for intracellular processes, EPR for extracellular environment), but temporal and spatial correlation of images cannot be achieved
Solution Approach 1:
The patent combines PET and EPR imaging modalities into a single integrated system, allowing simultaneous acquisition of both intracellular (PET) and extracellular (EPR) data with temporal and spatial correlation. The merged system includes a PET scanner with ring geometry and an EPR resonator with gradient coils, enabling coordinated measurement of tumor metabolism and microenvironment parameters.
Solution Approach 2:
The integrated PET-EPR system provides multi-functional capability by incorporating both imaging modalities into one platform. The system can simultaneously perform PET imaging for metabolic assessment and EPR imaging for microenvironment characterization, offering universal application for comprehensive tumor analysis without requiring separate standalone systems.
2Loss of information
If PET and EPR systems are integrated into a combined scanner, then temporal and spatial correlation of images can be achieved, but device complexity increases
Solution Approach 1:
The patent implements a nested configuration where the EPR resonator with gradient coils is positioned within the bore of the PET scanner ring. This nesting arrangement allows the EPR imaging system to be housed within the PET system structure, sharing common support infrastructure and reducing overall system complexity despite the integration of multiple modalities.
Solution Approach 2:
The integrated system is divided into distinct functional modules: the PET scanner component with its ring geometry and detectors, and the EPR resonator component with gradient coils. This segmentation allows independent optimization and maintenance of each modality while maintaining their integrated functionality for correlated imaging.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables temporal and spatial correlation of PET and EPR images, facilitating the simultaneous measurement of intracellular and extracellular components in complex environments, enhancing the understanding of tumor interactions and microenvironment dynamics.
Implementation Method 1
electron paramagnetic resonance imaging (EPR or EPRI)
Implementation Method 2
positron emission tomography (PET)
Implementation Method 3
one or more magnets configured to provide a magnetic field to the EPR resonator
Data Source
AI summary
Described herein are positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) systems and methods of use. In one example, a PET-EPRI system includes a PET-EPR insert, a PET scanner including one or more solid-state photodetectors, and a subject module that can house a subject for scanning. The PET-EPR insert includes an EPR resonator that can nest inside the PET scanner. The EPR resonator includes a resonator that can receive the subject module, a shield encircling the resonator and one or more rapid scan coils (RS-coils) positioned around the shield. The shield can prevent electrical coupling between the RS-coils and the resonator while being transparent to annihilation photons and magnetic field scans.