Pet Food Metabolite Modulation for White Blood Cell Control

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Solution Overview

Problem

Current pet food products do not effectively modulate white blood cells or neutrophils in companion animals, which are crucial for immune health, and there is a need for cost-effective nutritional enhancements that can specifically target these immune cells.

Innovation Solution

A pet food composition comprising protein, carbohydrates, fat, fiber, and specific metabolites that can increase or decrease white blood cells or neutrophils, developed through a predictive model identifying correlating metabolite compounds, allowing for tailored dietary adjustments to enhance immune health.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional pet food formulations are used, then production costs are reduced, but white blood cell and neutrophil modulation is ineffective

Engineering Contradiction:
Improveimmune health modulationVSAvoidproduction cost
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies parameter changes by identifying specific metabolites whose concentrations need to be adjusted to achieve desired immune modulation effects. The formulation changes the chemical composition parameters of the pet food by incorporating specific amounts of metabolites that correlate with white blood cell and neutrophil levels, thereby transforming a conventional formulation into one with proven immune health benefits.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs feedback mechanisms by using predictive models that correlate metabolite levels with immune cell counts. These models provide feedback on how dietary metabolite composition affects white blood cell and neutrophil levels, allowing for optimized formulations that achieve desired immune modulation while considering cost constraints.

Inventive Principle:
Principle #23Feedback

2Reliability

If metabolite levels are adjusted to modulate white blood cells or neutrophils, then immune health is improved, but production costs increase

Engineering Contradiction:
Improveimmune healthVSAvoidmetabolite concentration
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent optimizes the concentration parameters of specific metabolites in the pet food formulation. By identifying the precise amounts of metabolites needed to achieve 5% or greater modulation of white blood cells or neutrophils, the formulation balances immune health benefits with cost considerations, avoiding excessive metabolite addition.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent applies local quality by targeting specific metabolites with proven correlations to immune cell modulation rather than uniformly increasing all nutritional components. This focused approach adjusts only the necessary metabolite concentrations to achieve immune health goals, minimizing unnecessary cost increases.

Inventive Principle:
Principle #3Local quality

3Manufacturing precision

If a predictive model is used to identify metabolite compounds, then modulation precision is improved, but development complexity increases

Engineering Contradiction:
Improvemetabolite modulation precisionVSAvoidmodel development complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent uses predictive models that replicate the relationship between metabolite levels and immune cell counts based on observed correlations. These models serve as simplified copies of the complex biological systems, allowing for precise formulation development without requiring direct manipulation of complex biological variables during manufacturing.

Inventive Principle:
Principle #26Copying

Data Source

PatentEP3554257B1Compositions and methods that modulate white blood cells or neutrophils in a companion animal
Publication Date: 2023.07.12 SOCIETE DES PRODUITS NESTLE SA

AI summary

White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.