Petal-Shaped Occlusive Device for Aneurysm Neck Bridging
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Solution Overview
Problem
Current treatments for intracranial aneurysms, such as balloon- and stent-assisted coiling, face challenges with wide-necked aneurysms, including coil protrusion, increased procedural complexity and risk of clot formation, and the need for dual antiplatelet therapy, which is contraindicated in ruptured aneurysms. Additionally, flow diverters show limited efficacy in treating bifurcation aneurysms and require DAPT, increasing hemorrhagic risks.
Innovation Solution
An occlusive device with petal-shaped regions formed from tubular braids is deployed within the aneurysm to extend over the neck, preventing coil protrusion and engaging the aneurysm wall for secure placement, eliminating the need for implanted components in the parent vessel and reducing the risk of clot formation, thereby allowing treatment of wide-necked and ruptured aneurysms without DAPT.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If neck-bridging stents are permanently positioned in the parent vessel to prevent coil migration, then coil protrusion is prevented, but the risk of clot formation increases and dual antiplatelet therapy is required
Solution Approach 1:
The patent removes the stent component from the parent vessel and extracts only the essential function of preventing coil migration. The occlusive device achieves coil retention through its mesh structure and petal-shaped regions that engage with the aneurysm sac and neck, eliminating the need for stent support in the parent vessel and thereby eliminating the associated clot formation risk.
Solution Approach 2:
The patent introduces an intermediary occlusive device that positions itself at the aneurysm neck rather than in the parent vessel. This device acts as a mediator between the coils and the parent vessel, preventing coil migration without requiring permanent stent implantation. The device provides temporary structural support during the occlusion process without the long-term thrombogenicity of stents.
2Reliability
If flow diverters are positioned in the parent vessel to redirect blood flow, then aneurysm thrombosis is promoted, but dual antiplatelet therapy is required increasing hemorrhagic risk
Solution Approach 1:
The patent extracts the flow diversion function from the parent vessel and relocates it to the aneurysm sac. The occlusive device creates localized flow disruption within the aneurysm through its mesh structure, achieving thrombosis without requiring flow diverters in the parent vessel. This eliminates the need for DAPT and associated hemorrhagic risks.
Solution Approach 2:
The patent applies flow disruption locally within the aneurysm sac rather than globally in the parent vessel. The mesh structure and petal-shaped regions create localized turbulence and stasis within the aneurysm, promoting thrombosis only where needed. This localized approach avoids the systemic thrombogenic effects of parent vessel flow diverters.
3Reliability
If balloon or stent delivery systems are added to treat wide-necked aneurysms, then occlusion rate improves, but procedural complexity and treatment time increase
Solution Approach 1:
The patent merges the functions of coil retention and aneurysm occlusion into a single integrated occlusive device. The mesh structure and petal-shaped regions simultaneously prevent coil migration and promote thrombosis, eliminating the need for separate balloon or stent delivery systems. This unified approach maintains high occlusion rates while reducing procedural complexity.
Solution Approach 2:
The occlusive device performs multiple functions within a single structure: it provides mechanical support for coil retention, creates flow disruption for thrombosis, and engages with the aneurysm neck for secure positioning. This multi-functional design replaces the need for multiple separate devices (stent, balloon, coils) with a single versatile occlusive device.
Data Source
AI summary
Devices for treating vascular defects and associated systems and methods are disclosed herein. In some embodiments, for example, an occlusive device for treating an aneurysm includes a first mesh formed from a first tubular braid, the first mesh including a first petal-shaped region formed from a first flattened section of the first tubular braid. The first mesh can be coupled to a second mesh formed from a second tubular braid. The second mesh can include a second petal-shaped region formed from a second flattened section of the second tubular braid. When the occlusive device is deployed within the aneurysm, the first and second petal-shaped regions can extend at least partially over a neck of the aneurysm.