Petrolatum Aqueous Composition Stabilized by Nonionic Surfactants

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Solution Overview

Problem

Current aqueous compositions for ophthalmological and otolaryngological use struggle to effectively remove pollen and prevent allergic symptoms, as they often result in oil layer separation and precipitation when containing petrolatum, leading to reduced solubility and increased cell damage due to dry stress.

Innovation Solution

An aqueous composition comprising petrolatum and two or more nonionic surfactants, which inhibits oil layer separation and precipitation, enhancing solubility and reducing cell damage, while also effectively removing allergens like pollen from mucosal surfaces.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If petrolatum is added to aqueous composition for ophthalmological use, then pollen removal effect is improved, but oil layer separation and precipitation occur

Engineering Contradiction:

Improvepollen removal effectVSAvoidoil layer separation

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent introduces nonionic surfactants as intermediary substances to mediate between petrolatum and aqueous solution. The surfactants form micelles that solubilize petrolatum droplets, preventing oil layer separation while maintaining the pollen removal effect. This resolves the contradiction by adding a mediating component that enables compatibility between immiscible phases.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a composite aqueous composition system combining petrolatum, nonionic surfactants, and water. This composite formulation allows the hydrophobic petrolatum to be dispersed and stabilized within the hydrophilous aqueous phase through surfactant action, preventing separation while maintaining therapeutic effectiveness.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If one surfactant is used as solubilizing agent in aqueous composition containing petrolatum, then solubility is improved, but separation and precipitation of oil layer still occur

Engineering Contradiction:

Improvesolubility of petrolatumVSAvoidseparation and precipitation

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent combines multiple nonionic surfactants with different HLB values to create a synergistic solubilizing system. This combination of surfactants provides both steric stabilization and electrostatic repulsion, preventing oil layer separation more effectively than a single surfactant alone, while maintaining high petrolatum solubility.

Inventive Principle:

Principle #5Merging (Combining)

3Ease of manufacture

If conventional aqueous composition is used, then manufacturing is simple, but cell damage due to dry stress increases

Engineering Contradiction:

Improvemanufacturing simplicityVSAvoidcell damage due to dry stress

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent modifies the compositional parameters of conventional aqueous compositions by adding petrolatum and nonionic surfactants. This parameter change transforms the formulation into one that provides lipid supplementation to ocular surface cells, reducing dry stress and cell damage while maintaining ease of manufacture through standard pharmaceutical mixing processes.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively removes allergens, reduces allergic symptoms, and prevents cell damage from dry stress, providing a comfortable and efficient solution for ophthalmological and otolaryngological applications.

Implementation Method 1

an aqueous composition containing (A) a petrolatum and two or more (B) nonionic surfactants is capable of inhibiting separation and precipitation of an oil layer, and thus capable of significantly increasing the solubility of the petrolatum

Methodology Applied

Scientific EffectSurfactant: Surfactant

Implementation Method 2

an aqueous composition containing (A) a petrolatum and two or more (B) nonionic surfactants is capable of simply and effectively removing pollen attached to an ophthalmic or nasal mucosa

Methodology Applied

Scientific EffectSolubilization: Solvation

Implementation Method 3

an aqueous composition containing (A) a petrolatum and two or more (B) nonionic surfactants is capable of reducing cell damage due to dry stress (dried damage) on mucous membrane cells of eyes, of nose, and the like

Methodology Applied

Scientific EffectProtective barrier formation: Adsorption

Data Source

PatentUS11103464B2Aqueous composition for ophthalmological use or otolaryngological use

Publication Date: 2021.08.31 ROHTO PHARM CO LTD

AI summary

The present invention relates to an aqueous composition for ophthalmological use or otolaryngological use, the aqueous composition containing: (A) a petrolatum; and two or more (B) nonionic surfactants.