PGS Composite Vascular Graft with Overbraid for Thrombosis Resistance
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Solution Overview
Problem
Current cardiovascular grafts face complications such as restenosis, thrombosis, and long-term medication requirements, and existing small-diameter vascular grafts are prone to thrombi and intimal hyperplasia, limiting their effectiveness in treating cardiovascular disease.
Innovation Solution
A composite lumen made from a poly(glycerol sebacate) (PGS) matrix with a PGS thermoset filler, combined with an overbraid structure, provides a flexible, water-impermeable, and biodegradable scaffold that mimics natural tissue mechanics, allowing for endogenous regeneration of vascular structures without the need for extensive processing or active pharmaceuticals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If synthetic materials such as ePTFE and PET are used for vascular grafts, then availability and manufacturing ease are improved, but susceptibility to infection, thrombosis, and intimal hyperplasia increases
Solution Approach 1:
The patent employs a composite structure combining a textile-based three-dimensional hollow lumen with an elastic polymer coating. This composite material integrates the manufacturing advantages of synthetic textiles with the biological compatibility and thrombosis resistance of polymer coatings, creating a graft that is both easy to manufacture and reliable in preventing thrombosis and infection
Solution Approach 2:
The patent modifies the surface properties and mechanical parameters of the graft by applying an elastic polymer coating to the textile structure. This parameter change transforms the raw textile material into a biocompatible surface that resists thrombosis and infection while maintaining the structural integrity and ease of manufacture of the underlying textile framework
2Adaptability or versatility
If small-diameter grafts are used for vessels less than 6 mm, then applicability to smaller vessels is improved, but development of thrombi and intimal hyperplasia increases
Solution Approach 1:
The patent uses a flexible elastic polymer coating applied as a thin film over the textile graft structure. This flexible shell conforms to small vessel diameters while providing a thrombus-resistant surface, enabling the graft to be successfully implanted in vessels less than 6 mm in diameter without developing thrombi or intimal hyperplasia
3Ease of operation
If textile-based lumens are used, then flexibility and water-impermeability are improved, but structural strength and durability are reduced
Solution Approach 1:
The patent creates a composite structure where the textile-based three-dimensional hollow lumen provides flexibility and water-impermeability, while the elastic polymer coating adds structural strength and durability. The combination allows the graft to maintain both flexibility for easy implantation and sufficient strength for long-term durability in the vascular system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite lumen offers a durable, flexible, and kink-resistant vascular graft that can be used for small-bore vessels, promoting effective tissue regeneration and reducing complications like thrombosis and intimal hyperplasia, while being economical and easily stored for immediate use.
Implementation Method 1
The composite lumen offers a durable, flexible, and kink-resistant vascular graft that can be used for small-bore vessels, promoting effective tissue regeneration
Implementation Method 2
an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler
Data Source
AI summary
A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.