pH Indicator Swabs with Hydrogel Matrix for Wound Monitoring

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Solution Overview

Problem

Existing pH indicator systems for wound monitoring are cumbersome, prone to errors, and slow in detecting infections, requiring complex calibration and multiple steps, which delays treatment and affects outcomes.

Innovation Solution

Development of medical swabs with a crosslinked absorbent hydrogel matrix incorporating a pH indicator that changes color visibly to indicate the pH of biological fluids, allowing for rapid and accurate monitoring of wound pH without the need for additional equipment or calibration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional pH indicator systems are used for wound monitoring, then pH measurement capability is provided, but device complexity and ease of operation deteriorate due to requiring calibration and multiple steps

Engineering Contradiction:
ImprovepH measurement capabilityVSAvoidcalibration and multiple steps
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines the pH indicator, absorbent material, and swab structure into a single integrated device. The pH indicator is impregnated directly into the absorbent swab material, eliminating the need for separate calibration devices and multiple measurement steps. This merging of components resolves the technical contradiction by maintaining pH measurement precision while significantly reducing device complexity and improving ease of operation.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The swab is designed to be self-calibrating through its absorbent properties. When the swab absorbs wound exudate, the pH indicator automatically responds to the local pH environment without requiring external calibration. This self-service mechanism eliminates the calibration step and simplifies the measurement process while maintaining measurement precision.

Inventive Principle:
Principle #25Self-service

2Measurement precision

If conventional pH indicator systems are used for wound monitoring, then pH measurement capability is provided, but productivity deteriorates due to slow detection and treatment delays

Engineering Contradiction:
ImprovepH measurement capabilityVSAvoiddetection speed and treatment timing
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The pH indicator is pre-loaded into the absorbent swab material during manufacturing, preparing the device for immediate use. When applied to the wound, the swab instantly begins absorbing exudate and the indicator immediately responds to pH changes. This preliminary preparation eliminates setup time and enables rapid detection, improving productivity while maintaining measurement precision.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The integrated design allows the measurement process to be completed in a single step - the swab is applied, absorbs fluid, and provides immediate colorimetric readout. This eliminates intermediate steps such as transferring samples to separate indicator solutions or waiting for calibration, rushing through the measurement process to enable faster detection and treatment intervention.

Inventive Principle:
Principle #21Skipping (Rushing through)

3Measurement precision

If conventional pH indicator systems are used, then pH detection is possible, but reliability deteriorates due to errors in complex procedures

Engineering Contradiction:
ImprovepH detection capabilityVSAvoiderror rate in measurement
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

By merging the pH indicator and absorbent material into a single integrated swab, the patent eliminates multiple transfer steps and handling operations that are prone to errors. The indicator remains fixed within the absorbent matrix, preventing contamination and ensuring consistent contact with wound exudate. This integration maintains pH detection precision while significantly improving reliability by reducing procedural error sources.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables convenient, rapid, and reliable detection of infection by providing a simple, one-step visual assessment of wound pH, facilitating early diagnosis and potentially reducing treatment delays and errors.

Implementation Method 1

a crosslinked absorbent hydrogel matrix at the surface

Methodology Applied
Scientific EffectAbsorption: Absorption (physical)

Implementation Method 2

crosslinked absorbent hydrogel matrix

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Implementation Method 3

a pH indicator retained within the crosslinked absorbent hydrogel matrix. The pH indicator exhibits a visually detectable color that is indicative of the pH of a fluid in contact with the pH indicator

Methodology Applied
Scientific EffectpH indicator color change: Photochromism

Data Source

PatentUS12196684B2pH indicator swabs for biomonitoring and diagnostics
Publication Date: 2025.01.14 UNIVERSITY OF SOUTH CAROLINA
  • US12196684B2 patent drawing
  • US12196684B2 patent drawing
  • US12196684B2 patent drawing

AI summary

Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.