PHA-Coated Aerosol-Cooling Element for ROS Quenching

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Solution Overview

Problem

Existing aerosol-generating articles do not adequately reduce the presence of harmful reactive oxygen species (ROS) in the inhaled aerosol, which are toxic and associated with various diseases.

Innovation Solution

Incorporating a polyhydroxyalkanoate (PHA)-coated aerosol-cooling element with longitudinally extending channels downstream of the aerosol-forming substrate to quench ROS in the aerosol.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If conventional materials (metallic foil, polymeric material, paper) are used for the aerosol-cooling element, then the structural integrity and cooling function are maintained, but the ability to quench reactive oxygen species (ROS) is insufficient

Engineering Contradiction:
ImproveROS levels in inhaled aerosolVSAvoidhealth safety effectiveness
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent changes the chemical composition parameter of the aerosol-cooling element by incorporating PHA coating on the polymeric sheet material. This parameter change enables the material to chemically interact with and quench ROS through antioxidant properties, transforming the material from a passive cooling structure to an active ROS-quenching component.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite structure by coating PHA (a natural polymer with antioxidant properties) onto a synthetic polymeric sheet (such as polyolefin). This composite material combines the structural integrity and thermal properties of the synthetic polymer with the ROS-quenching capabilities of the natural PHA polymer, achieving both cooling function and health safety.

Inventive Principle:
Principle #40Composite materials

2Ease of manufacture

If the aerosol-cooling element is made from a single-layer polymeric sheet, then the manufacturing process is simple, but the ROS quenching efficiency is limited

Engineering Contradiction:
Improvemanufacturing complexityVSAvoidROS presence in aerosol
Core Design Contradiction:
Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent applies PHA coating to the polymeric sheet in advance during the manufacturing process, before the aerosol-cooling element is installed in the vaping device. This preliminary action ensures that the ROS-quenching capability is built-in from the start, eliminating the need for post-manufacturing treatments or complex assembly procedures while maintaining manufacturing simplicity.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent modifies the surface properties and chemical composition of the polymeric sheet by adding the PHA coating layer. This parameter change enhances the material's chemical reactivity toward ROS without significantly complicating the manufacturing process, as the coating can be applied using standard coating techniques.

Inventive Principle:
Principle #35Parameter changes

3Temperature

If the aerosol-cooling element uses a pleated structure with longitudinally extending channels, then the surface area for cooling is increased, but the structural complexity increases

Engineering Contradiction:
Improveaerosol cooling efficiencyVSAvoidaerosol-cooling element structure
Core Design Contradiction:
TemperatureVSDevice complexity

Solution Approach 1:

The patent divides the aerosol-cooling element into multiple longitudinal channels separated by pleats. This segmentation increases the internal surface area available for heat exchange and ROS quenching, while the repetitive pleated pattern keeps the manufacturing process relatively simple through standardized forming operations.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent transforms a flat two-dimensional polymeric sheet into a three-dimensional pleated structure with longitudinal channels. This dimensional transformation dramatically increases the surface area volume ratio, enhancing both cooling efficiency and ROS quenching capacity without requiring a completely different structural approach.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Significantly reduces ROS levels in the inhaled aerosol, enhancing health safety and consumer appeal by mitigating oxidative stress-related health risks.

Implementation Method 1

the aerosol-cooling element is formed by a sheet of a polymeric composition that is pleated to define a plurality of longitudinally extending channels, wherein the sheet is coated with at least one PHA, the aerosol-generating article being suitable for use in an aerosol-generating device to quench reactive oxygen species (ROS) in the aerosol produced by the aerosol-generating article

Methodology Applied
Scientific EffectROS quenching: Redox Reactions

Data Source

PatentEP3998875B1Aerosol-generating article suitable for use in an aerosol-generating device
Publication Date: 2025.09.10 BIO ON SPA
  • EP3998875B1 patent drawingFigure 1~2
  • EP3998875B1 patent drawingFigure 3~4

AI summary

An aerosol-generating article comprising an aerosol-forming substrate and at least one element including at least one polyhydroxyalkanoate (PHA), said at least one element being placed downstream with respect to the aerosol forming substrate. According to a preferred embodiment, the aerosol-generating article comprises: an aerosol-forming substrate; a support element located immediately downstream of the aerosol-forming substrate; an aerosol-cooling element located downstream of the support element; and an outer wrapper circumscribing the aerosol-forming substrate, the support element and the aerosol-cooling element; wherein the aerosol-cooling element includes at least one PHA. The at least one element including at least one polyhydroxyalkanoate (PHA) is able to quench reactive oxygen species (ROS) which are inevitably present in the volatile substances produced by heating the aerosol-forming substrate.