Pharmaceutical Coating Film with Flaky Substance for Taste Masking
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Solution Overview
Problem
Existing coated solid pharmaceutical preparations fail to effectively mask unpleasant tastes and odors of pharmacologically active substances and are prone to discoloration over time, with existing film-forming polymers being inadequate in density and requiring longer production times and higher costs.
Innovation Solution
A coated solid pharmaceutical preparation using a film comprising a film-forming polymer and a flaky substance, which is applied to the preparation to suppress unpleasant tastes and odors and prevent discoloration, while reducing the amount of coating material needed.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a film-forming polymer coating is applied to mask unpleasant taste and odor, then the unpleasant taste and odor are reduced, but the film density is insufficient leading to inadequate protection and discoloration
Solution Approach 1:
The patent applies a composite coating film comprising multiple polymers (polyvinyl alcohol and polyacrylic acid or copolymer) in specific ratios (95:5 to 50:50 by mass), combined with inorganic fillers (talc, titanium oxide, or silicon dioxide at 1-50 mass% relative to solid content). This composite structure creates a denser, more effective barrier that simultaneously masks unpleasant taste/odor and prevents discoloration, resolving the contradiction between basic masking function and protection reliability.
2Reliability
If a thicker coating film is applied to improve protection against discoloration and odor, then stability is improved, but production time increases
Solution Approach 1:
The patent optimizes the composition parameters of the coating film, specifically the ratio of polyvinyl alcohol to polyacrylic acid (95:5 to 50:50 by mass) and the content of inorganic fillers (1-50 mass% relative to solid content). This parameter optimization achieves sufficient protection against discoloration and odor with a thinner, more efficient coating layer, thereby reducing production time while maintaining or improving stability.
3Object-affected harmful factors
If conventional coating materials are used to reduce unpleasant taste and odor, then some masking effect is achieved, but the effect is insufficient and additional coating material is required
Solution Approach 1:
The patent employs a composite coating system combining polyvinyl alcohol with polyacrylic acid or copolymer in optimized ratios (95:5 to 50:50 by mass), along with inorganic fillers (talc, titanium oxide, or silicon dioxide at 1-50 mass% relative to solid content). This composite formulation enhances the masking efficiency per unit mass, achieving superior unpleasant taste and odor reduction with less coating material compared to conventional single-polymer coatings.
Data Source
AI summary
Provided is a coated solid pharmaceutical preparation which not only makes it difficult to perceive the unpleasant taste and/or unpleasant odor of pharmacologically active substances when taken but also does not easily discolor over time. In the coated solid pharmaceutical preparation, a solid pharmaceutical preparation containing a pharmacologically active substance is coated with a film containing a film-forming polymer and a flaky substance.