Pharmaceutical Form with Water-Soluble Coloring Agent for Immediate Beverage Detection
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Solution Overview
Problem
Current methods fail to provide immediate detection of illicitly introduced psychoactive substances in drinks without relying on detection devices or kits, posing a risk for unsuspecting victims.
Innovation Solution
Incorporating water-soluble coloring agents like indigocarmine, erythrosine, brilliant blue FCF, and tartrazine into a pharmaceutical form that changes the color of the drink upon introduction, allowing for immediate visual detection of the substance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If a film-coated tablet is used to slow dissolution, then the tablet's structural integrity is improved, but the detection time is delayed
Solution Approach 1:
The tablet is divided into two functional parts: a film coating layer that maintains structural integrity and prevents premature dissolution, and an inner core containing the psychoactive substance and water-soluble coloring agent that rapidly dissolves and colors the beverage upon contact with liquid, enabling immediate detection
Solution Approach 2:
A water-soluble coloring agent is incorporated into the tablet formulation that immediately dissolves and changes the color of the beverage upon contact, providing visual detection of the substance's presence without requiring waiting for film coating dissolution
2Device complexity
If no detection mechanism is incorporated, then the pharmaceutical form remains simple and unobtrusive, but the victim cannot detect the illicit substance
Solution Approach 1:
A water-soluble coloring agent is incorporated into the pharmaceutical form that immediately dissolves and changes the color of the beverage upon contact, providing visual detection of the substance's presence without requiring complex detection devices or kits
Solution Approach 2:
The pharmaceutical form itself provides the detection function through its intrinsic coloring agent, eliminating the need for external detection devices or kits, making the detection capability inherent to the substance rather than requiring additional equipment
3Measurement precision
If a detection kit is used, then detection accuracy is improved, but the system becomes less accessible to general public
Solution Approach 1:
The pharmaceutical form itself provides the detection function through its intrinsic coloring agent that immediately dissolves and colors the beverage, eliminating the need for external detection devices or kits and making detection universally accessible without requiring specialized equipment
Solution Approach 2:
The water-soluble coloring agent provides immediate visual detection through color change in the beverage, offering simple and accessible detection that does not require complex instrumentation or specialized procedures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables immediate and visible detection of the substance in various drink types, including clear and opaque beverages, enhancing victim awareness and preventing unauthorized substance administration.
Implementation Method 1
dissolving in a drink a solid pharmaceutical form comprising an active ingredient and at least 0.05 mg, preferably 0.2 to 5 mg, even more preferably 0.3 to 2 mg of at least one orally acceptable water-soluble coloring agent
Data Source
AI summary
The present invention relates to a method for combating chemical submission, which comprises: putting into solution, in a beverage, a pharmaceutical form comprising an active ingredient and at least 0.05 mg, preferably from 0.2 to 5 mg, even more preferentially from 0.3 to 2 mg of at least one water-soluble colouring agent chosen from: indigocarmine or E 132, erythrosine or E 127, brilliant blue FCF, alphazurine FG, fast green FCF, quinzarine green SS, orange II, tartrazine and Sunset yellow FCF, detecting the pharmaceutical form, said detection being characterized by the immediate change in colour of the beverage; it also relates to the use of said colorant for combating chemical submission, and also to a non-film-coated solid pharmaceutical form comprising said colorant.