Pharmaceutical Preparation Device with Sterile Filtration
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Solution Overview
Problem
Current methods for preparing pharmaceutical or biopharmaceutical substances are time-consuming and require careful handling to achieve precise volumes, concentrations, and components, especially under high-purity and sterile conditions, which is not efficiently addressed by devices designed for beverage preparation.
Innovation Solution
A device comprising a preparation container with ingredients, a storage container for a fluid that can be fed in a monitored manner via a feed line, and a receiving container, equipped with sterile or virus filters, allowing for quick, reliable, and easy preparation of pharmaceutical or biopharmaceutical substances in small to medium volumes under high-purity and sterile conditions, with options for cartridge or pad preparation containers and flexible arrangements for multiple containers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If devices designed for beverage preparation are used, then the preparation process becomes simpler, but the purity and sterility conditions cannot be met
Solution Approach 1:
The patent employs disposable preparation containers (capsules or cartridges) that are pre-filled with pharmaceutical substances. These single-use containers eliminate the need for complex sterilization procedures while ensuring sterility and purity, as each container is sterile by design and discarded after one use, combining ease of operation with reliable sterility conditions.
2Manufacturing precision
If manual preparation methods are used, then precise volumes and concentrations can be achieved, but the preparation time increases significantly
Solution Approach 1:
The pharmaceutical substances are pre-filled into preparation containers (capsules or cartridges) with precise dosing and concentrations before use. This preliminary action ensures that when the container is used, the precise volume and concentration requirements are already met, eliminating the need for time-consuming manual measurement and mixing while maintaining high precision.
Solution Approach 2:
The preparation container is designed to automatically deliver the correct volume and concentration of pharmaceutical substance when activated. The system requires minimal operator intervention, as the pre-configured container self-regulates the preparation parameters, thereby reducing preparation time while maintaining precision.
3Quantity of substance
If small volumes of pharmaceutical substances are prepared, then the required precision is high, but the handling complexity increases
Solution Approach 1:
The pharmaceutical substance is segmented into individual single-use preparation containers, each containing a specific small volume with pre-determined precision. This segmentation allows each container to be optimized for its specific dosage requirements without requiring complex handling procedures for small volumes, as each unit is self-contained and sterile.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, reliable, and easy preparation of pharmaceutical or biopharmaceutical substances in precise volumes and concentrations, suitable for both small and larger amounts, ensuring sterility and virus-free conditions through the use of filters and controlled fluid feeding and mixing processes.
Implementation Method 1
equipped with sterile or virus filters, allowing for quick, reliable, and easy preparation of pharmaceutical or biopharmaceutical substances under high-purity and sterile conditions
Data Source
AI summary
A method for the preparing mixtures of pharmaceutical or biopharmaceutical substances (11, 11″) includes arranging a preparation container (3, 3′, 3″) already made up with ingredients in a receptacle (2) of a device (1, 1′, 1″) feeding a fluid (10) from a storage container (4, 4″) into the preparation container (3, 3″) via a feed line (6), preparing the ingredients with the fluid (10, 10″) into a substance mixture (11, 11″), and removing the substance mixture (11, 11″) from the preparation container (3, 3′, 3″) into a receiving container via a discharge line (12, 12′, 12″). A device also is provided for carrying out the method.