Pharmaceutical Bag With Cyclic Polyolefin Inner Layer

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Solution Overview

Problem

Existing plastic containers for pharmaceutical products with high affinity for plastics face challenges in achieving superior storage stability while maintaining low production costs.

Innovation Solution

The plastic container features an innermost layer formed from an amorphous polymer, polymerized from olefin monomers with a cyclic hydrocarbon skeleton, and a port member made from a crystalline polyolefin without a cyclic hydrocarbon skeleton, optimizing the material composition to ensure stable storage of pharmaceutical ingredients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a cyclic polyolefin-based resin is used for the port member to prevent sorption and permeation of pharmaceutical products, then storage stability is improved, but material cost increases and productivity decreases due to longer welding time

Engineering Contradiction:

Improvestorage stabilityVSAvoidproductivity

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The invention applies different material qualities to different parts of the container: the bag body uses cyclic polyolefin resin for sorption prevention, while the port member uses conventional polyolefin resin for cost efficiency. This local differentiation resolves the contradiction by optimizing each component's material properties according to its specific functional requirements.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The container is divided into distinct segments (bag body and port member) with different material compositions. The bag body segment uses cyclic polyolefin resin to prevent sorption, while the port member segment uses conventional polyolefin resin to reduce cost and improve welding efficiency, thereby resolving the productivity-stability contradiction.

Inventive Principle:

Principle #1Segmentation

2Reliability

If a cyclic polyolefin-based resin is used for the port member to prevent sorption of pharmaceutical products, then storage stability is improved, but material cost increases

Engineering Contradiction:

Improvestorage stabilityVSAvoidmaterial cost

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The port member uses conventional polyolefin resin which is cheaper and easier to manufacture, accepting that it may have shorter service life or lower performance compared to cyclic polyolefin resin, thereby resolving the cost-stability contradiction.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If a PP-based resin layer directly contacts the contents to reduce sterilization-induced content reduction, then sterilization stability is improved, but sorption of contents during long-term storage occurs

Engineering Contradiction:

Improvesterilization stabilityVSAvoidcontent reduction

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The bag body is structured with multiple layers where the cyclic polyolefin resin layer faces the contents to prevent sorption during storage, while the PP-based resin layer provides sterilization stability. This layered segmentation allows each material to perform its optimal function without compromising the other.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The bag body uses a composite structure combining cyclic polyolefin resin and PP-based resin in different layers. The cyclic polyolefin layer prevents sorption during storage, while the PP layer provides sterilization stability, thereby resolving the contradiction between sterilization stability and content loss prevention.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration enables stable storage of pharmaceutical ingredients during sterilization and subsequent static storage, while allowing for cost-effective mass production of the plastic container.

Implementation Method 1

adsorption or absorption (such a physiochemical behavior may be referred to as 'sorption' in some cases) on or permeation to a film formed from a common crystalline polyolefin-based resin

Methodology Applied

Scientific EffectSorption: Sorption

Implementation Method 2

adsorption or absorption (such a physiochemical behavior may be referred to as 'sorption' in some cases), or permeation to a film formed from a common crystalline polyolefin-based resin

Methodology Applied

Scientific EffectPermeation: Permeation

Data Source

PatentUS12233025B2Plastic container

Publication Date: 2025.02.25 ZACROS CORP

AI summary

A plastic container has superior storage stability for pharmaceutical ingredients exhibiting a high affinity to plastic and can be mass-produced at low cost. The container has a bag body formed into a bag shape by a sheet member with a storage part on the inside thereof, and a tubular port member attached to the bag body, wherein one end of the tubular port member communicates with the storage part and an opening part of the other end is exposed outside of the bag body. The sheet member is formed from two or more layers including a base resin layer and an innermost layer formed from an amorphous polymer, as a main component, formed by polymerizing at least one type of olefin monomer, having a cyclic hydrocarbon skeleton, and the port member is formed from a resin having a crystalline polyolefin having no cyclic hydrocarbon skeleton, as a main component.