Phellinus linteus Fermented Extract for Sarcopenia Muscle Mass
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Solution Overview
Problem
Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, is not effectively controlled by current pharmaceutical products, and existing treatments primarily rely on exercise, disease management, and nutritional interventions.
Innovation Solution
A method utilizing Phellinus linteus as an active ingredient, involving a multistage incubation and extraction process to produce a fermented product extract, which is administered to maintain muscle function and mass through water or ethanol extracts, with specific dosage ranges for animal and human subjects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pharmaceutical products are used to control sarcopenia, then muscle mass loss can be addressed, but current pharmaceutical products are not effective for sarcopenia control
Solution Approach 1:
The patent changes the chemical parameters of the treatment by using fermented extracts of Phellinus linteus with specific pH ranges (2-6) and fermentation conditions, transforming an ineffective pharmaceutical approach into an effective natural product-based treatment that maintains muscle mass and function in sarcopenia patients
Solution Approach 2:
The fermented extract of Phellinus linteus acts as an intermediary substance that mediates between the patient's muscle tissue and the treatment effect, containing bioactive compounds produced during fermentation that specifically target muscle protein synthesis and prevent muscle atrophy without requiring complex pharmaceutical formulations
2Duration of action of stationary object
If exercise and nutritional interventions are used to delay sarcopenia, then muscle function can be maintained, but these methods require significant patient compliance and time
Solution Approach 1:
The fermented Phellinus linteus extract contains pre-formed bioactive compounds that have already been synthesized during the fermentation process, providing immediate therapeutic effect when administered, eliminating the need for patients to invest time in exercise programs or dietary modifications to achieve muscle protection
3Reliability
If Phellinus linteus is used to improve sarcopenia, then muscle mass and function are maintained, but the optimal dosage and administration method must be determined
Solution Approach 1:
The patent optimizes the administration parameters by specifying dosage ranges (400-600 mg/kg/day for mice, 2300-2500 mg/kg/day for humans) and using fermented extracts with controlled pH (2-6), making the treatment easy to administer while maintaining high effectiveness in preventing muscle mass loss and maintaining muscle function
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively maintains myotube diameters, muscle mass, and muscular endurance, delaying or preventing sarcopenia-related losses without toxicity, as demonstrated by animal experiments.
Implementation Method 1
a ferment incubation step is performed on the third mycelium with a second liquid medium under 15° C. to 30° C. for 3 days to 21 days to obtain the fermented product of the P. linteus
Data Source
AI summary
The invention provides a method for improving sarcopenia of a subject in need thereof by using Phellinus linteus, in which the method includes administering an effective dose of composition to the subject, and the composition includes Phellinus linteus (NITE BP-03321 and BCRC 930210) as an effective substance. By using the aforementioned composition including an extract of a fermented product of the Phellinus linteus and/or its derivative, diameters of myotubes, amounts of muscles and muscle muscular endurance can be maintained, thereby improving sarcopenia.