Phenolic Antiseptic Compositions for Mucosal Tissue Decolonization

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Solution Overview

Problem

Current antimicrobial agents face challenges such as resistance development, irritation issues, and ineffectiveness on moist tissues like the nasal passages and wounds, particularly in decolonizing Staphylococcus aureus and MRSA, and they often require frequent application with potential for tissue damage.

Innovation Solution

Development of antimicrobial compositions containing halogenated phenols, bisphenols, and anilides at higher concentrations, combined with hydrophobic phases and surfactants, which are less likely to cause irritation and maintain efficacy on moist tissues, reducing the risk of resistance and providing broad-spectrum activity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antibiotics are used for nasal decolonization, then antimicrobial activity is achieved, but resistance development occurs

Engineering Contradiction:

Improveantimicrobial activityVSAvoidresistance development

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent changes the chemical parameter from antibiotic molecules to phenolic antiseptic molecules, fundamentally altering the mechanism of action from specific metabolic pathway inhibition to nonspecific cell membrane disruption and protein denaturation, thereby eliminating resistance development while maintaining antimicrobial activity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the traditionally harmful property of phenols (irritation at high concentrations) into a benefit by formulating them at optimized concentrations that provide superior antimicrobial activity and tissue decolonization while maintaining safety, especially in sensitive areas like the nasal passages

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Reliability

If strong antiseptics are used to achieve broad-spectrum activity, then antimicrobial efficacy is improved, but tissue irritation increases

Engineering Contradiction:

Improvebroad-spectrum antimicrobial activityVSAvoidtissue irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the concentration parameter of phenolic antiseptics to achieve the minimum effective concentration that provides broad-spectrum activity while minimizing irritation, and modifies the chemical structure parameter by using halogenated phenols and bisphenols with specific properties that reduce irritation potential

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite formulations by combining phenolic antiseptics with hydrophobic phases and surfactants, forming a composition that enhances antimicrobial efficacy while reducing individual component irritation through synergistic interactions

Inventive Principle:

Principle #40Composite materials

3Reliability

If antiseptics are applied at high concentrations to ensure efficacy, then antimicrobial activity is improved, but tissue damage risk increases

Engineering Contradiction:

Improveantimicrobial efficacyVSAvoidtissue damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the concentration parameter from the traditionally high concentrations required for conventional antiseptics to optimized lower concentrations of phenolic compounds that achieve equivalent or superior efficacy with reduced tissue damage risk

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs phenolic compounds that act rapidly and effectively on contact, providing immediate antimicrobial action that allows for shorter contact times and reduced cumulative exposure, thereby minimizing tissue damage while maintaining efficacy

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

4Reliability

If conventional antiseptics are used on moist tissues, then some antimicrobial activity is achieved, but effectiveness is reduced due to inactivation by organic compounds

Engineering Contradiction:

Improveantimicrobial activityVSAvoidinactivation by organic matter

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent changes the chemical parameter from conventional antiseptics like iodine and quaternary ammonium compounds to phenolic antiseptics, which have different chemical properties that prevent inactivation by organic compounds present in nasal secretions and moist tissues

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses phenolic compounds that maintain their antimicrobial activity in the presence of organic matter, providing reliable and consistent performance in moist environments like the nasal passages without requiring reapplication or showing reduced efficacy

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Data Source

PatentUS8198326B2Phenolic antiseptic compositions and methods of use

Publication Date: 2012.06.12 SOLVENTUM INTELLECTUAL PROPERTIES CO

AI summary

Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including an antiseptic such as halogenated phenols, bisphenols, diphenyl ethers, anilides and derivatives thereof, and combinations thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).