Phenyl Cyclohexanone Derivatives for Pain Treatment
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Solution Overview
Problem
Current drugs for treating bipolar depression, major depressive disorder, neuropathic pain, and chronic pain, such as complex regional pain syndrome, often come with unwanted central nervous system (CNS) effects and a potential for abuse, necessitating the development of therapeutics that do not exhibit these drawbacks.
Innovation Solution
Development of phenyl cyclohexanone derivatives as active agents, which can be administered in pharmaceutical compositions to treat various conditions like bipolar depression, major depressive disorder, schizophrenia, Alzheimer's dementia, amyotrophic lateral sclerosis, complex regional pain syndrome, chronic pain, or neuropathic pain, without causing CNS effects or abuse potential.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drugs are used to treat bipolar depression, major depressive disorder, neuropathic pain, and chronic pain, then therapeutic effects are achieved, but unwanted central nervous system effects and abuse potential occur
Solution Approach 1:
The patent modifies the chemical structure of phenyl cyclohexanone derivatives by changing molecular parameters (substituents at specific positions) to alter pharmacological properties. This allows achieving therapeutic effects while reducing CNS penetration and abuse potential through precise structural parameter optimization
Solution Approach 2:
The invention introduces specific functional groups at particular locations (positions 2, 6, and other designated positions) on the cyclohexanone ring to create local chemical properties that selectively target peripheral pain receptors while avoiding CNS effects. The local substitution pattern creates differentiated pharmacological behavior
Data Source
AI summary
Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by administering such active agents to a patient are described.