Phenylethylamine Salts for Athletic Performance
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Solution Overview
Problem
Current dietary supplements and pharmaceutical compositions for enhancing athletic performance and treating erectile dysfunction are inadequate in terms of speed of onset, duration of effect, and bioavailability, leading to impractical dosing requirements and side effects such as tolerance and decreased sexual performance.
Innovation Solution
Development of salts of Phenylethylamines with deprotonated inorganic acids, specifically nitric acid or nitrous acid, which form stable compounds like Phenylethylamine Nitrate and Phenylethylamine Nitrite, improving bioavailability, plasma half-life, and vasodilation, thereby enhancing athletic performance and sexual function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If base PEA or other salts of PEA are used, then athletic performance enhancement is achieved, but the onset time is slow and duration is short
Solution Approach 1:
The patent applies parameter changes by converting base PEA into salt forms (nitrate, nitrite, sulfate, phosphate, chloride) which fundamentally alter the pharmacokinetic parameters including onset time, duration, and bioavailability. This chemical form transformation resolves the contradiction by enabling both faster onset and extended duration simultaneously
Solution Approach 2:
The patent creates composite chemical compounds by combining PEA with inorganic acid anions to form stable salt structures. These composite salts exhibit synergistic properties that overcome the limitations of base PEA, achieving both rapid onset and prolonged action duration
2Quantity of substance
If base PEA or other salts of PEA are used, then athletic performance enhancement is achieved, but oral bioavailability is low requiring higher doses
Solution Approach 1:
The patent changes the chemical parameters of PEA by forming salts with inorganic acids, which dramatically improves oral bioavailability. This allows the same therapeutic effect to be achieved with lower quantities of the active compound, resolving the contradiction between dose quantity and bioavailability reliability
3Productivity
If high doses of base PEA are administered, then athletic performance enhancement is achieved, but tolerance develops and sexual performance decreases
Solution Approach 1:
The patent changes the chemical form of PEA to salt variants which modify the pharmacodynamic profile. This allows achieving the same productivity (athletic enhancement) at lower effective doses, thereby reducing the generation of harmful effects such as tolerance and vaso-constriction
Data Source
AI summary
Disclosed are salts of 2-phenylethylamines and deprotonated inorganic acids, compositions and formulations containing the same, and methods of making and using the salts, compositions and formulations.