Phenyllactic Acid Composition for HAS2-Driven Skin Moisturization

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Solution Overview

Problem

The moisturizing effects of phenyllactic acid on the skin are not well understood, and existing methods do not effectively increase hyaluronic acid production to combat dryness caused by environmental factors like blue light and UV rays.

Innovation Solution

A composition containing phenyllactic acid, a strain with phenyllactic acid production ability, or its lysate, culture, or fermentation is administered to increase hyaluronic acid production in skin cells, using a Lactobacillus plantarum strain, particularly Lactobacillus plantarum APsulloc 331261, to enhance skin moisturization and protect against dryness.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If phenyllactic acid is used for its known antibacterial and skin-whitening effects, then harmful bacteria are inhibited and tyrosinase activity is suppressed, but its moisturizing effects remain unknown and hyaluronic acid production is not effectively increased

Engineering Contradiction:

Improvemoisturizing effectVSAvoidunknown moisturizing mechanism

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent discovers that phenyllactic acid self-servicefully increases hyaluronic acid production in skin cells through upregulation of HAS2 gene expression, thereby providing moisturizing effects without requiring external intervention or additional ingredients

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent identifies that phenyllactic acid changes the expression parameter of hyaluronic acid synthesizing enzymes (HAS2 gene) in skin cells, transforming the known antibacterial/whitening properties into a new moisturizing function through molecular-level parameter modification

Inventive Principle:

Principle #35Parameter changes

2Object-affected harmful factors

If existing skincare methods are used to combat dryness, then some moisturizing effect is provided, but they do not effectively increase hyaluronic acid production to protect against blue light and UV ray induced dryness

Engineering Contradiction:

Improveprotection from blue light and UV raysVSAvoidhyaluronic acid production

Core Design Contradiction:

Object-affected harmful factorsVSProductivity

Solution Approach 1:

The patent uses phenyllactic acid, a metabolite that can be produced through fermentation by lactic acid bacteria, as a cost-effective alternative to expensive conventional moisturizing agents, providing sustained hyaluronic acid production stimulation

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent combines phenyllactic acid with skin cell biology (HAS2 gene expression system) to create a composite effect where the acid stimulates endogenous hyaluronic acid production, providing enhanced protection against environmental stressors

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively increases hyaluronic acid production, providing skin moisturization and protection from dryness caused by environmental stressors, and can be used in cosmetic, quasi-drug, and health functional food compositions.

Implementation Method 1

phenyllactic acid is a metabolite derived from phenylalanine, and is transformed into phenyllactic acid by lactate dehydrogenase after the intermediate metabolite phenylpyruvic acid is generated

Methodology Applied

Scientific EffectFermentation: Fermentation

Implementation Method 2

transformed into phenyllactic acid by lactate dehydrogenase

Methodology Applied

Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 3

The composition comprising at least one selected from the group consisting of phenyllactic acid; a strain having phenyllactic acid production ability; a lysate thereof, a culture thereof, a fermentation thereof, and an extract of the strain, lysate, culture or fermentation thereof as an active ingredient, according to an embodiment of the present disclosure, can effectively increase the expression of hyaluronic acid producing enzymes in skin cells

Methodology Applied

Scientific EffectGene expression regulation:

Data Source

PatentUS20250302712A1Composition for skin moisturizing comprising phenyllactic acid

Publication Date: 2025.10.02 AMOREPACIFIC CORP

AI summary

Disclosed herein are a method for moisturizing a skin and a method for producing phenyllactic acid. An effective amount of a composition comprising at least one selected from the group consisting of phenyllactic acid; a strain having phenyllactic acid production ability; a lysate thereof; a culture thereof; a fermentation thereof; and an extract of the strain, lysate, culture or fermentation thereof, according to an embodiment of the present disclosure, can effectively increase the expression of hyaluronic acid producing enzymes in skin cells, thereby protecting the skin from dryness caused by blue light, ultraviolet rays, etc., and therefore can be administered to a skin moisturizing cosmetic composition, a quasi-drug composition, a general food composition, or a health functional food composition.