Phlomis umbrosa and Polygala tenuifolia Extracts for Insomnia Treatment

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Solution Overview

Problem

Current insomnia treatments, such as central nervous system inhibitors, benzodiazepines, and pyrazolopyrimidine-based sleeping pills, often cause side effects like narcolepsy, depression, drug resistance, and severe intoxication upon long-term use.

Innovation Solution

A composition using extracts of Phlomis umbrosa Turcz. and Polygala tenuifolia Willd., obtained with solvents like water, alcohol, or ethyl acetate, and potentially purified, is administered to improve sleep quality without side effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If central nervous system inhibitors or benzodiazepines are used to treat insomnia, then sleep quality is improved, but side effects such as narcolepsy, depression, and drug resistance occur

Engineering Contradiction:

Improvesleep qualityVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses natural plant extracts (Phlomis umbrosa and Polygala tenuifolia) instead of synthetic pharmaceuticals, treating insomnia through traditional herbal medicine that acts as a temporary, non-accumulating solution without long-term side effects or dependency

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent introduces natural plant extracts as intermediary substances that mediate between the patient's physiological needs and the treatment goal, using bioactive compounds from plants to gently regulate sleep patterns without the harsh effects of central nervous system inhibitors

Inventive Principle:

Principle #24Intermediary (Mediator)

2Loss of time

If pyrazolopyrimidine-based sleeping pills are used for insomnia, then sleep onset is accelerated, but severe drug intoxication occurs with long-term administration

Engineering Contradiction:

Improvesleep latencyVSAvoiddrug intoxication

Core Design Contradiction:

Loss of timeVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters from synthetic pyrazolopyrimidine compounds to natural plant extract compositions, altering the pharmacological profile to achieve sleep promotion without severe intoxication effects through the synergistic action of multiple natural bioactive compounds

Inventive Principle:

Principle #35Parameter changes

3Reliability

If benzodiazepines are administered repeatedly, then sleep quality is maintained initially, but drug resistance develops

Engineering Contradiction:

Improvesleep qualityVSAvoidtreatment effectiveness duration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The natural plant extracts work through multiple biochemical pathways simultaneously, allowing the body's natural sleep-regulating systems to function while being gently supported, thereby avoiding the development of resistance that occurs with single-pathway pharmaceutical interventions

Inventive Principle:

Principle #25Self-service

Data Source

PatentEP2412378B1Composition for prevention or treatment of insomnia

Publication Date: 2014.04.23 NATURALENDO TECH

AI summary

Provided is a composition for preventing or treating insomnia. The composition includes, as an active ingredient, extract of Phlomis umbrosa Turcz. or a combination thereof with extract of Polygala tenuifolia Willd. Particularly, the combination of extract of Phlomis umbrosa Turcz. with extract of Polygala tenuifolia Willd. enables recovery of the sleep of patients suffering from insomnia nearly to that of normal persons. The composition for treating insomnia uses active ingredients that have been used as Chinese traditional medicines, and thus is safe to the human body.