Phloretin Ferulic Acid Ascorbic Acid Composition Stability

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Solution Overview

Problem

Conventional Vitamin C formulations for skin are plagued by stability issues, which hinder their effectiveness in preventing radical-induced damage and promoting collagen production, thereby failing to adequately address photo-aging and other skin issues like skin cancer and inflammation.

Innovation Solution

A cosmetic composition combining phloretin, a mixture of ferulic acid and ascorbic acid, and a non-aqueous organic solvent with water as a co-solvent, which stabilizes the active ingredients and enhances their antioxidant properties, providing effective treatment for radical-induced skin damage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional Vitamin C formulations are applied to skin, then antioxidant protection and collagen stimulation are provided, but stability issues prevent consistent effectiveness

Engineering Contradiction:
Improveeffectiveness of antioxidant protectionVSAvoidstability of Vitamin C formulation
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent combines phloretin with a mixture of ferulic acid and ascorbic acid (Vitamin C) to create a stable formulation. This merging of multiple active ingredients resolves the stability issue while maintaining or enhancing the antioxidant protection and collagen stimulation benefits.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing phloretin, ferulic acid, and ascorbic acid in specific proportions. This composite material approach creates a stable composition that overcomes the inherent instability of conventional Vitamin C formulations while providing reliable antioxidant protection.

Inventive Principle:
Principle #40Composite materials

2Stability of the object's composition

If phloretin is combined with ferulic acid and ascorbic acid, then stability and antioxidant efficacy are improved, but formulation complexity increases

Engineering Contradiction:
Improvestability of active ingredientsVSAvoidformulation complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent specifies precise parameter ranges for each ingredient: phloretin at 0.1-10% w/w, ferulic acid at 0.2-5% w/w, and ascorbic acid at 5-20% w/w. By controlling these parameters within defined ranges, the formulation achieves stability while managing complexity through standardized specification ranges.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly reduces UVA-induced erythema and persistent pigment darkening, demonstrating improved stability and efficacy in preventing skin damage and promoting collagen production.

Implementation Method 1

Application of antioxidants can help prevent radical-induced damage in skin. These radicals attack the collagen layer of the skin and break it down

Methodology Applied
Scientific EffectAntioxidant: Oxidation

Implementation Method 2

at least one non-aqueous organic solvent, and water as a co-solvent, which stabilizes the active ingredients and enhances their antioxidant properties

Methodology Applied
Scientific EffectSolvation: Solvation

Data Source

PatentEP1837056B1Anti-aging composition containing phloretin
Publication Date: 2016.08.17 LOREAL SA
  • EP1837056B1 patent drawing
  • EP1837056B1 patent drawing
  • EP1837056B1 patent drawing

AI summary

An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives; (b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.