Negatively Charged Phospholipid Dispersion for Stable Hot Drinks
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Solution Overview
Problem
Existing formulations of lipophilic and poorly water-soluble biologically active compounds face challenges in absorption due to limited solubility and stability issues, requiring high-shear homogenization and synthetic surfactants for stable colloidal dispersions, which are not feasible for household use.
Innovation Solution
A premix formulation containing a fraction of negatively charged phospholipids, which can be deprotonated by weak basic salts, allowing for the formation of a stable phospholipid dispersion in warm water without high-shear homogenization or high HLB surfactants, using an air- or oxygen-impermeable container for storage and preparation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If conventional formulations use synthetic surfactants with high HLB values and high-shear homogenization, then stable colloidal dispersions are achieved, but the complexity of equipment and process increases making household use infeasible
Solution Approach 1:
The invention changes the chemical parameters of the surfactant system by using phospholipids with specific HLB values (8-16) instead of conventional high HLB synthetic surfactants. This parameter change allows stable colloidal dispersion formation without requiring high-shear homogenization equipment, making the formulation suitable for household use while maintaining dispersion stability
Solution Approach 2:
The invention replaces complex, expensive industrial homogenization equipment with simple, disposable mixing containers that can be used in household settings. The single-use mixing container approach eliminates the need for specialized equipment while achieving the desired colloidal dispersion through simple mixing actions
2Reliability
If bioactives are formulated in concentrated premixes with oils and phospholipids, then bioavailability is enhanced, but protection from hydrolysis and oxidation during storage becomes challenging
Solution Approach 1:
The invention uses an inert or oxygen-impermeable mixing container to create a protective environment that prevents oxidation of the oil and bioactive components during storage and mixing. This inert environment atmosphere approach maintains the stability of the formulation while preserving bioavailability
Solution Approach 2:
The invention performs preliminary protection by formulating the bioactives in a concentrated premix with oils and phospholipids before use, and storing it in a protected environment. This preliminary action prevents degradation during storage while maintaining the ability to enhance bioavailability when activated by adding water or aqueous beverage
3Stability of the object's composition
If significant amounts of carrier oil are used to deliver lipophilic bioactives, then solubility is improved, but the quantity of substance administered increases beyond feasible doses
Solution Approach 1:
The invention uses phospholipids as an intermediary substance between the lipophilic bioactives and the aqueous environment. The phospholipids form colloidal structures that solubilize the bioactives without requiring large amounts of carrier oil, thus improving solubility while keeping the total quantity of substances administered at feasible levels
Solution Approach 2:
The invention creates a composite colloidal system consisting of phospholipids, oils, and bioactives in specific ratios. This composite material approach allows efficient delivery of lipophilic bioactives with reduced carrier oil content by leveraging the emulsifying and solubilizing properties of the phospholipid-bioactive complex
4Reliability
If phospholipids are used as natural colloid-forming excipients, then bioaccessibility is improved, but phospholipids themselves are sensitive to hydrolysis and oxidation when not properly stored
Solution Approach 1:
The invention stores phospholipids in an inert or oxygen-impermeable mixing container that protects them from oxidation and hydrolysis during storage. This protected environment maintains phospholipid stability while preserving their ability to enhance bioaccessibility when activated for use
Solution Approach 2:
The invention uses phospholipids that can self-assemble into colloidal structures when water or aqueous beverage is added, eliminating the need for complex external stabilization systems. The phospholipids serve themselves by forming protective colloidal structures that simultaneously protect the bioactives and maintain their own stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the preparation of a homogeneous, stable colloidal phospholipid dispersion suitable for oral intake, enhancing bioavailability and bioaccessibility of bioactive ingredients without specialized equipment, using a mixture of phospholipids, oils, and polyols in a container that can be easily mixed with warm water.
Implementation Method 1
Phospholipids can help form liposomes (phospholipid bilayer vesicles) but also micro- or nanoemulsions, as well as (mixed) micelles that can protect and carry a range of delicate bioactives
Implementation Method 2
Phospholipids are natural lipidic colloid-forming excipients that are capable of creating high quality stable lipid dispersions
Implementation Method 3
The key element of the invention that allows for this to be achieved is the improved dispersion capacity of the phospholipids in the premix that is obtained and ensured by having a certain fraction of negatively charged phospholipids in the premix, which can be added to the premix and/or be created by treating deprotonable phospholipids present in the premix with weak basic salt
Implementation Method 4
many biologically actives—and in particular those that are of natural origin—are not only vulnerable to degradation once ingested but are prone to hydrolysis and oxidation when formulated and stored in the form of a comestible aqueous health product
Implementation Method 5
phospholipids are sensitive to hydrolysis and oxidation when not properly stored and preserved
Data Source
AI summary
The invention relates to mixtures comprising one or more phospholipids, wherein at least 2 wt % of the phospholipids bears a net negative charge, and/or is deprotonable, whereby the mixture comprises a weak basic salt; one or more oils, butters and/or triglycerides; one or more lipophilic or poorly water-soluble biologically active ingredients; and one or more liquid or solid polyols, sugars, monohydric and/or poly hydric alcohols. The invention further relates to sealed and air- or oxygen-impermeable and liquid-im-permeable containers comprising such mixture and the preparation thereof.