Phospholipid Foaming Agent Liquid Composition for Topical Application
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Solution Overview
Problem
The development of liquid pharmaceutical compositions that form a foam for topical application is time-consuming and often results in inhomogeneous foams due to variations in mechanical foaming techniques, making it difficult to achieve consistent foam volumes and stabilities.
Innovation Solution
A method involving a liquid composition with a phospholipid foaming agent and a pharmaceutically acceptable active agent, mechanically foamed without propellants, where the concentration of ingredients is varied to achieve specific foam volumes and stabilities using the SITA measurement method, ensuring reproducible and consistent foam production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If mechanical foaming techniques are varied to achieve desired foam properties, then foam volume and stability can be adjusted, but the development time increases and foam homogeneity decreases
Solution Approach 1:
The invention changes the chemical composition parameters of the liquid composition, specifically incorporating phospholipids and surfactants with optimized concentrations (0.1-10% w/w phospholipids, 0.05-5% w/w surfactants) to achieve consistent foam properties without extensive mechanical parameter adjustments
Solution Approach 2:
The invention uses composite foaming systems combining phospholipids with surfactants (ionic, nonionic, or amphoteric) to create a synergistic effect that produces homogeneous and stable foams more reliably than single-component systems, reducing development time and improving consistency
2Volume of stationary object
If mechanical foaming parameters are adjusted to achieve specific foam volumes, then foam volume can be controlled, but foam stability becomes inconsistent
Solution Approach 1:
The invention optimizes chemical composition parameters including phospholipid concentration (0.1-10% w/w), surfactant concentration (0.05-5% w/w), and pH (5-8) to achieve simultaneous control of foam volume and stability, making the foam less sensitive to mechanical parameter variations
Solution Approach 2:
The composite system of phospholipids combined with surfactants creates a more stable foam structure where the phospholipid head groups and surfactant molecules work synergistically to stabilize air-liquid interfaces, maintaining consistent foam stability across different foam volumes
3Ease of operation
If propellants are used to generate foam, then foam generation is easier, but the composition becomes less suitable for topical pharmaceutical application
Solution Approach 1:
The invention removes propellants from the composition entirely, relying instead on mechanical activation through pumping and mixing mechanisms to generate foam, thereby ensuring suitability for topical pharmaceutical application while maintaining ease of operation
Solution Approach 2:
The invention replaces chemical propellant-driven foam generation with a mechanical foam generation system using pumps, mixers, and aerators, substituting chemical propulsion with mechanical energy input to achieve propellant-free foamable compositions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method significantly simplifies the development process, allowing for the creation of foams with controlled volumes and stabilities, enhancing the uniform distribution and penetration of active ingredients, thereby improving the efficacy and application of pharmaceuticals.
Implementation Method 1
the liquid composition is capable of mechanically foaming without an additional propellant
Implementation Method 2
a phospholipid foaming agent
Data Source
AI summary
A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.