Phospholipid Hydrogel for Nutraceutical Solubility
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Solution Overview
Problem
Naturally occurring nutraceutical compounds like quercetin and emodin face challenges due to their low water solubility and low oral bioavailability, limiting their development as therapeutic agents for diseases such as cancer and cardiovascular disease.
Innovation Solution
The development of a hydrogel composition that includes a phospholipid complex with solubilized phospholipids and nutraceutical compounds, enhancing their solubility and bioavailability for oral administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If nutraceutical compounds are administered orally, then ease of administration is improved, but water solubility and oral bioavailability deteriorate
Solution Approach 1:
The patent employs phospholipids as intermediary substances that form complexes with nutraceutical compounds. These phospholipid complexes act as mediators between the hydrophobic nutraceutical compounds and the aqueous environment, enabling oral administration while improving water solubility and bioavailability through the amphiphilic nature of phospholipids
Solution Approach 2:
The patent creates composite formulations consisting of phospholipids and nutraceutical compounds. This composite material combines the properties of both components, where the phospholipid matrix provides water solubility and the nutraceutical compound provides therapeutic activity, thereby resolving the contradiction between ease of oral administration and poor solubility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation significantly improves the solubility and oral bioavailability of nutraceutical compounds, potentially increasing their therapeutic effectiveness in treating various diseases.
Implementation Method 1
a solubilized phospholipid and a solubilized nutraceutical compound
Data Source
AI summary
In general, the present disclosure is directed to compositions and methods for formulating thereof for oral administration. The composition may be in the form of a hydrogel. The hydrogel may include a phospholipid complex comprising a solubilized phospholipid and a solubilized nutraceutical compound.