Phospholipid Vesicle Tissue Marker for Stable Imaging
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Solution Overview
Problem
Current tissue-markers face challenges in precisely identifying and marking tissue positions within organs, especially when visible light cannot be transmitted, leading to diffusion and increased surgical burdens, and existing markers lack stability and fixation during procedures.
Innovation Solution
A medical tissue-marker comprising a vesicle formed by combining phospholipids and near-infrared fluorescent dyes, incorporated into a hydrophilic solvent with an emulsion of X-ray contrast mediums, stabilized by an emulsifier to form clusters that remain stable and visible for extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If a tissue-marker is fabricated by combining indocyanine green and gelatin for visible light absorption, then the marker can be observed by an endoscope camera, but the marker diffuses through tissues in an early stage making identification difficult
Solution Approach 1:
The patent combines indocyanine green with gelatin to create a composite tissue-marker that maintains both visible light absorption properties and improved stability within the tissue, preventing premature diffusion while retaining optical detectability
Solution Approach 2:
The patent modifies the physical and chemical parameters of the marker composition by combining indocyanine green with gelatin, changing the diffusion characteristics and stability parameters to achieve both observability and sustained positioning
2Ease of operation
If a vesicle formed by combining phospholipid and near-infrared fluorescent dye is incorporated into hydrophilic solvent, then the marker can be detected from outside the organ, but the marker immediately diffuses after administration causing marking point to blur
Solution Approach 1:
The patent introduces a biodegradable polymer as an intermediary carrier that temporarily holds the near-infrared fluorescent dye within a controlled structure, allowing external detection while preventing immediate diffusion and maintaining marking precision until the polymer degrades
Solution Approach 2:
The patent uses a biodegradable polymer shell to encapsulate the fluorescent dye, creating a flexible containment structure that prevents diffusion while allowing the marker to be administered and detected, with the shell degrading over time to release the dye
3Stability of the object's composition
If iodized poppy oil ethyl ester is protected by phospholipid to enhance dispersibility and retentivity, then the marker stability improves, but the dispersion liquid has high fluidity causing low fixation and leakage
Solution Approach 1:
The patent creates a composite structure combining phospholipid protection with biodegradable polymer encapsulation, achieving both enhanced dispersibility and retentivity while the polymer matrix provides the necessary fixation strength to prevent leakage
Solution Approach 2:
The patent applies different material properties to different regions of the marker system - the phospholipid layer provides surface stability and dispersibility, while the biodegradable polymer core provides structural strength and fixation, creating local quality differentiation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise identification and marking of tissue positions from outside the organ, maintaining stability and reducing unnecessary tissue excision, while allowing for clear X-ray CT imaging and fluorescent visualization.
Implementation Method 1
a near-infrared fluorescent dye which emits a fluorescent light in a near-infrared light wavelength range
Implementation Method 2
a vesicle formed by combining a phospholipid and a near-infrared fluorescent dye
Implementation Method 3
a cluster in which a plurality of capsules are formed and aggregated by an emulsifier
Data Source
AI summary
A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.