Phosphonoalamide Compounds for Broad-Spectrum Bacterial Control
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Solution Overview
Problem
There is a need for new compositions and methods to control plant, animal, and insect pathologies caused by bacteria, as existing modalities are inadequate or non-existent.
Innovation Solution
Development of compounds comprising phosphonoalamides of specific formulas, which can be formulated into pharmaceutical or agricultural compositions, and methods for their use in controlling undesirable bacterial populations and treating bacterial infections in plants and animals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing modalities for controlling plant, animal, and insect pathologies are used, then current treatments are available, but the control effectiveness is poor or non-existent for many pathologies
Solution Approach 1:
The patent modifies the chemical structure of phosphonate natural products by changing molecular parameters (R1, R2, R3 substituents) to create novel compounds with enhanced activity against diverse bacterial pathogens, including those resistant to existing treatments
Solution Approach 2:
The invention creates composite molecular structures combining phosphonate groups with various organic substituents (alkyl, aryl, cycloalkyl groups) to achieve broad-spectrum antimicrobial activity while maintaining specificity against different pathogen types
2Reliability
If new phosphonate compounds are developed, then antimicrobial activity is improved, but the complexity of compound structure increases
Solution Approach 1:
The patent divides the molecular structure into distinct functional segments: a phosphonate core group and variable substituent groups (R1, R2, R3), allowing systematic variation of specific regions to optimize activity while maintaining overall structural manageability
Solution Approach 2:
Different regions of the molecule are assigned different functional properties: the phosphonate group provides antimicrobial activity while the substituent groups (R1-R3) are optimized locally for specific biological activities, solubility, and pharmacokinetic properties
Data Source
AI summary
Disclosed herein are compositions and methods of making and use thereof. For example, disclosed herein are compounds comprising a phosphonoalamide of Formula (I) and/or Formula (II). In some examples, the compound is a salt, such as a salt form of Formula (I) and/or Formula (II) with a counterion. Also disclosed herein are compositions comprising any of the compounds disclosed herein, such as pharmaceutical and/or agricultural compositions. Also disclosed herein are methods of use of any of the compounds and/or compositions disclosed herein, for example to control an undesirable population, such as a microbe (e.g., bacteria). Also disclosed herein are methods of reducing the activity of bacteria; reducing bacterial population; killing bacteria; treating, preventing, inhibiting, and/or ameliorating a disease or disorder in a plant or a subject in need thereof, such as a microbial (e.g., bacterial) infection; or a combination thereof using any of the compounds and/or compositions disclosed herein.