Phosphorus Nicotinamide Riboside Compounds for NAD+ Modulation
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Solution Overview
Problem
Current understanding of NAD biology is limited in pharmacologic intervention and manipulation of the NAD pathway in living cells and tissues, necessitating improved compositions and methods for modulating NAD+ levels for therapeutic applications.
Innovation Solution
Development of compounds and compositions that modulate nicotinamide adenine dinucleotide (NAD+) levels, including pharmaceutical compositions combining NAD+ modulating compounds with active pharmaceutical ingredients, to increase intracellular NAD+ levels for treating diseases and improving cell and tissue survival.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If current understanding of NAD biology is used, then basic NAD function is maintained, but pharmacologic intervention capability is limited
Solution Approach 1:
The patent introduces NAD+ modulating compounds as intermediary substances that bridge the gap between current NAD biology understanding and desired therapeutic outcomes. These compounds serve as mediators that can safely adjust NAD+ levels without disrupting fundamental NAD functions, enabling pharmacologic intervention while maintaining reliability of basic NAD biology.
Solution Approach 2:
The patent applies parameter changes by modifying intracellular NAD+ concentration levels through administered compounds. By controlling the concentration parameter of NAD+ in cells, the invention enables pharmacologic intervention capability while maintaining the reliability of basic NAD functions through regulated parameter adjustment rather than fundamental changes.
2Reliability
If NAD+ levels are increased in cells, then therapeutic benefits are achieved, but complexity of compositions increases
Solution Approach 1:
The patent applies universality by designing NAD+ modulating compounds that can serve multiple functions: they increase intracellular NAD+ levels for therapeutic benefit while also being compatible with various active pharmaceutical ingredients. This multi-functionality reduces overall composition complexity by using a versatile core compound rather than requiring separate specialized components for each therapeutic effect.
Solution Approach 2:
The patent combines NAD+ modulating compounds with active pharmaceutical ingredients into integrated pharmaceutical compositions. This merging approach achieves therapeutic benefits through the combined action of increasing NAD+ levels while incorporating disease-specific active ingredients, thereby reducing the need for separate complex treatment regimens and simplifying the overall therapeutic composition.
Data Source
AI summary
The invention relates to compounds and compositions for modulation of nicotinamide adenine dinucleotide (NAD+). The invention also relates to methods of making such compounds and compositions. The invention relates to pharmaceutical compositions containing one or more NAD+ modulating compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and/or improving cell and tissue survival.