Phosphorylcholine Polymer Regulator for Factor-Deficient APTT Testing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing blood coagulation tests struggle to accurately detect specimens with coagulation abnormalities such as coagulation factor deficiencies or LA positivity, as they lack sensitivity and specificity in regulating blood coagulation times.
Innovation Solution
A blood coagulation time regulator for specimens deficient in coagulation factors VIII, IX, or XI, utilizing a polymer with 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit, optionally combined with other monomers and additives, to regulate and measure coagulation times in activated partial thromboplastin time (APTT) tests.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional APTT measurement reagents are used, then the test can be performed with standard reagents, but the sensitivity and specificity for detecting coagulation abnormalities (such as FVIII, FIX, or FXI deficiency) are insufficient
Solution Approach 1:
The invention changes the chemical composition parameters of the APTT reagent by incorporating a polymer with specific functional groups (carboxyl, hydroxyl, or amino groups) and controlling its molecular weight and concentration. This parameter modification enables the reagent to specifically interact with and detect FVIII, FIX, or FXI deficiency, thereby improving sensitivity and specificity while maintaining reliable measurement accuracy.
2Measurement precision
If the blood coagulation time is not regulated, then the natural coagulation process is preserved, but the ability to precisely detect coagulation abnormalities is compromised
Solution Approach 1:
The invention introduces a polymer with specific functional groups as an intermediary substance that mediates between the blood specimen and the detection system. This polymer regulates the coagulation time by interacting with coagulation factors, creating a controlled environment that enables precise detection of abnormalities while simplifying the overall measurement process through standardized reagent addition and timing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The regulator enables precise detection of coagulation abnormalities by effectively regulating and measuring blood coagulation times, enhancing the sensitivity and accuracy of APTT measurements.
Implementation Method 1
a blood coagulation time regulator for a blood specimen deficient in coagulation factor VIII, IX, or XI in activated partial thromboplastin time (APTT) measurement
Data Source
AI summary
A blood coagulation time regulator for a blood specimen deficient in coagulation factor VIII, factor IX, or factor XI in activated partial thromboplastin time measurement includes, as an active ingredient, a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit. An activated partial thromboplastin time measurement reagent contains a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constitutional unit and an amino acid.