Photoacoustic Imaging Device Using Continuous Wave Laser Modulation

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Solution Overview

Problem

Current photoacoustic imaging technologies face challenges in achieving high-resolution imaging at a low cost, particularly in the depth direction, due to the need for expensive pulse lasers in existing multiphoton excitation methods.

Innovation Solution

A photoacoustic imaging device utilizing a semiconductor laser light source emitting continuous waves, combined with a frequency shifting unit and a variable focus lens, to generate intensity-modulated light that induces thermal expansion and acoustic waves, allowing for high-resolution imaging without the need for expensive pulse lasers.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a short pulse laser is used to generate acoustic waves through instantaneous thermal expansion, then imaging depth information can be obtained via arrival time, but the device cost becomes high

Engineering Contradiction:
Improvedepth resolutionVSAvoiddevice cost
Core Design Contradiction:
Measurement precisionVSEase of manufacture

Solution Approach 1:

The patent changes the laser operating parameters from pulsed mode to continuous wave mode with intensity modulation. By modulating the intensity of continuous laser light at ultrasonic frequencies (MHz band), the system generates acoustic waves without requiring expensive short pulse lasers, thereby reducing device cost while maintaining imaging capability

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent applies periodic intensity modulation to the continuous laser beam at ultrasonic frequencies. This periodic modulation creates rhythmic thermal expansion in the tissue, generating acoustic waves at the modulation frequency. The periodic nature of this action enables depth encoding through frequency analysis rather than time-of-flight measurement

Inventive Principle:
Principle #19Periodic action

2Ease of manufacture

If a continuous wave laser with intensity modulation is used instead of short pulse laser, then device cost is reduced, but depth determination by arrival time becomes impossible

Engineering Contradiction:
Improvedevice costVSAvoiddepth resolution
Core Design Contradiction:
Ease of manufactureVSMeasurement precision

Solution Approach 1:

The patent transitions from time-domain depth encoding (arrival time) to frequency-domain depth encoding. By modulating the continuous laser at different ultrasonic frequencies and analyzing the received signals in the frequency domain, depth information is extracted through spectral analysis rather than temporal measurement, adding a frequency dimension to the imaging process

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The patent replaces the temporal measurement mechanism (time-of-flight) with a frequency-based detection mechanism. Instead of measuring when acoustic waves arrive, the system modulates light intensity at ultrasonic frequencies and detects the resulting acoustic signals through their frequency characteristics, substituting mechanical time measurement with optical frequency modulation

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Device complexity

If resolution in depth direction is determined by acoustic wave properties, then imaging is simplified, but high resolution cannot be achieved

Engineering Contradiction:
Improveimaging simplicityVSAvoiddepth resolution
Core Design Contradiction:
Device complexityVSMeasurement precision

Solution Approach 1:

The patent makes the light source perform multiple functions: it serves as both the illumination source and the acoustic wave generator through intensity modulation. The modulated continuous laser simultaneously provides optical excitation and acoustic signal generation, eliminating the need for separate pulsed laser systems and complex acoustic transducers while achieving high depth resolution

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables high-resolution photoacoustic imaging at a lower cost by using continuous wave lasers and a variable focus lens to modulate light frequencies, generating acoustic waves with high specificity and resolution in the depth direction.

Implementation Method 1

a frequency shifting unit configured to shift a frequency of light by causing a Doppler effect

Methodology Applied
Scientific EffectDoppler effect: Doppler Effect

Implementation Method 2

The photoacoustic effect is a phenomenon that molecules having absorbed the light energy releases heat and an acoustic wave is generated as a result of volume expansion due to the heat

Methodology Applied
Scientific EffectPhotoacoustic effect: Photoacoustic Effect

Implementation Method 3

an acoustic wave is generated as a result of volume expansion due to the heat

Methodology Applied
Scientific EffectThermal expansion: Thermal Expansion

Data Source

PatentEP3287080B1Photoacoustic wave detecting device, and photoacoustic imaging device
Publication Date: 2022.08.31 YOKOGAWA ELECTRIC CORP
  • EP3287080B1 patent drawingFigure 1
  • EP3287080B1 patent drawingFigure 2
  • EP3287080B1 patent drawingFigure 3

AI summary

The objective of the invention is to make it possible to provide a high-resolution photoacoustic imaging device at low cost. This photoacoustic wave detecting device is provided with: a beam splitter (111) which splits emitted light from a light source; an optical physical property shifting unit (120) which changes at least one physical property of the split beams in such a way that the split beams interfere with one another; a lens (140) into which each split beams enters parallel to the optical axis; and an acoustic detecting unit (150) which detects an acoustic wave generated in a region of an observation target at the focal point of the lens (140).