Photocurable Liquid Adhesive Kit for Tissue Sealing
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Solution Overview
Problem
There is a need for improved and alternative tissue adhesives that can effectively form a diphenolic crosslinked polymer hydrogel when photocured, particularly for use in surgical procedures and medical applications, as existing adhesives may not provide adequate properties such as stability and ease of use.
Innovation Solution
A photocurable liquid adhesive kit is provided, containing an aqueous liquid with polymers having phenolic groups and a photoactivatable metal ligand complex, which, when mixed with an electron acceptor, forms a diphenolic crosslinked polymer hydrogel upon photocuring, maintaining a liquid state at room temperature and curing effectively with visible light.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing tissue adhesives are used, then adhesion function is provided, but stability and ease of use are inadequate
Solution Approach 1:
The adhesive system is divided into separate components (phenolic polymer solution and crosslinking agents) that are mixed only when needed. This segmentation allows each component to be optimized independently for stability while the mixing process provides ease of use through simple combination before application.
Solution Approach 2:
The phenolic polymer is pre-prepared in a stable solution form with controlled molecular weight and phenol content. This preliminary preparation ensures stability is achieved in advance, while the final crosslinking step provides the adhesive function when needed, improving ease of use.
2Strength
If polymers with phenolic groups are used to form diphenolic crosslinked hydrogel, then adhesion strength is improved, but complexity of preparation increases
Solution Approach 1:
The patent controls specific parameters of the phenolic polymer including molecular weight (2,000-500,000 Da), phenol content (0.1-10 mmol/g), and molecular weight distribution (PDI < 2.0). By optimizing these parameters, strong adhesion is achieved while keeping the preparation process manageable through defined specifications rather than complex procedures.
Solution Approach 2:
The adhesive comprises a composite system with phenolic polymer as the base material and crosslinking agents (metal ligand complex and electron acceptor) as functional additives. This composite approach provides strong adhesion through diphenolic crosslinking while maintaining relatively simple preparation by combining well-defined components.
3Ease of operation
If adhesive remains liquid at room temperature for ease of application, then ease of operation is improved, but stability of polymer structure may be compromised
Solution Approach 1:
The adhesive is designed to remain in liquid phase at room temperature for easy application, then undergoes phase transition to gel phase upon photocuring. The phenolic polymer solution maintains liquid state with controlled viscosity, and the diphenolic crosslinking induces gelation to provide structural stability after application.
Solution Approach 2:
The patent replaces mechanical crosslinking or chemical crosslinking requiring harsh conditions with photocuring using visible or UV light. This substitution allows the adhesive to remain stable in liquid form during storage and application, then transitions to a stable gel structure through light-induced crosslinking without compromising polymer integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables the formation of a stable and effective diphenolic crosslinked polymer hydrogel that can be used in surgical procedures and medical applications, providing improved adhesion and tissue sealing without the need for mechanical means, while maintaining a liquid state at room temperature for ease of application.
Implementation Method 1
photocurable liquid adhesive effective to form a diphenolic crosslinked polymer hydrogel when photocured
Implementation Method 2
a photoactivatable metal ligand complex
Implementation Method 3
an electron acceptor. The liquid preparation and the electron acceptor can be mixed to prepare a photocurable liquid adhesive
Implementation Method 4
effective to form a diphenolic crosslinked polymer hydrogel when photocured
Data Source
AI summary
Described are photocurable liquid adhesives, kits for preparing photocurable liquid adhesives, and methods for their preparation and use. Kits can include first and second components that can be mixed to prepare a photocurable liquid adhesive. The first component can include a liquid preparation including an aqueous liquid, one or more polymers containing phenolic groups, and a photoactivatable metal ligand complex. The second component can include an electron acceptor. Mixing the first component and the second component can create a photocurable liquid adhesive. The first and second components can be packaged in containers such as syringes, and the kits can include the containers and a cannulated coupler for fluidly coupling the containers to mix the container contents to prepare the photocurable liquid adhesive. A syringe dispensing tip and/or a light source for curing the photocurable liquid adhesive can also be included in the kits. Advantageous photocurable liquid adhesives are described that, absent curing, remain in flowable liquid form during typical temperatures of storage and use. The adhesives can include in or as a phenolic group-containing polymer component one or more of collagen, phenol enriched collagen, gelatin, phenol enriched gelatin, a collagen peptide composition, or a phenol enriched collagen peptide composition.