Photon Enhanced Bone Growth System Using Light Therapy
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Solution Overview
Problem
Current treatments for inflammation and bone growth are often slow and associated with significant side effects, and there is a need for methods to improve the efficacy and reduce adverse reactions of anti-inflammatory medications and bone growth agents.
Innovation Solution
The use of light therapy, specifically red and infrared light irradiation, in conjunction with medications such as teriparatide or abaloparatide, to enhance ATP production and activate gene transcription for anti-inflammatory and bone growth pathways.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional anti-inflammatory medications and bone growth agents are used, then therapeutic effects are achieved, but treatment duration is prolonged and side effects increase
Solution Approach 1:
The patent applies low-level light therapy (LLLT) with specific wavelengths (red light around 630-680nm and infrared light around 780-950nm) to change the physical parameters of tissue treatment. This optical energy stimulation accelerates cellular metabolism, ATP production, and gene expression, thereby speeding up the therapeutic process without increasing medication dosage or intensity.
Solution Approach 2:
The patent introduces light therapy as an intermediary mechanism that mediates between conventional medications and the target tissues. The light energy acts as a catalyst that enhances the biological response to medications by stimulating mitochondrial function, increasing blood flow, and promoting cellular regeneration, thus reducing the time required for therapeutic effects while maintaining medication safety profiles.
2Reliability
If conventional anti-inflammatory medications and bone growth agents are used, then therapeutic effects are achieved, but adverse reactions and side effects increase
Solution Approach 1:
The patent merges conventional pharmacological treatment with physical light therapy to create a synergistic treatment approach. By combining medications with LLLT, the patent achieves enhanced therapeutic effects at lower medication doses, thereby reducing the burden of side effects while maintaining or improving treatment efficacy.
Solution Approach 2:
The patent changes the treatment modality by introducing optical energy parameters (wavelength, intensity, duration) that directly stimulate biological processes without the chemical side effects associated with high-dose medications. This parameter-based approach allows for precise control of therapeutic effects while minimizing adverse reactions.
3Loss of time
If light therapy is applied with medications, then treatment duration is reduced, but treatment complexity increases
Solution Approach 1:
The patent uses light therapy devices as intermediaries that can be integrated into existing treatment protocols. The devices are designed to deliver specific wavelengths of light that penetrate tissues to stimulate cellular processes, working in conjunction with medications to accelerate healing without requiring complex surgical interventions or specialized equipment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly accelerates the resolution of inflammation and bone growth, reducing treatment duration and minimizing side effects by targeting specific areas with focused light therapy.
Implementation Method 1
Phototherapy is also used for certain cosmetic dermatological conditions. Procedures to remove unwanted hair, remove vascular lesions or pigmentation, eliminate acne, and rejuvenate the skin, for example, are becoming common. These treatments typically use light in either ultraviolet light.
Implementation Method 2
FIG. 10 illustrates a therapeutic pathway targeted by either teriparatide or abaloparatide with photon enhanced activation of gene transcription for osteoblast.
Data Source
AI summary
The present disclosure relates generally to a therapeutic system and method to manage and modulate inflammation by reducing inflammation with enhanced anti-inflammatory measures. Using a light source such as light emitting diodes (LEDs) or a laser light source, the photons can be used to applied to increase the efficacy of medicine on the organ (i.e., disease site) that needs treatment by imparting the light rays only to the site rather than the whole body. The photons produced by the light source increase adenosine triphosphate (ATP) to improve the functional selectivity of G Protein-Coupled Receptors (GPCR). With the increased efficacy of medicines to the disease site, the dosage of medicine can be reduced to minimize the side effects in particular to other parts of the body. The treatment may be used to treat inflammation caused by corona virus of 2019 (COVID-19) infection. The photon irradiation treatment can be used to enhance bone growth with parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP).