Phototherapy Imaging with Fluorescence Overlay for Treatment Confirmation

The patent combines multiple imaging modalities (narrow band light imaging and fluorescence imaging) into a single integrated imaging system. The superimposed image generator merges the narrow band light image showing blood flow changes with the fluorescence image showing drug distribution, creating a composite image that provides both structural and functional information about treatment effect with high precision.

The patent adds a new dimension to treatment evaluation by introducing fluorescence imaging that visualizes drug distribution and activation status. This complementary dimension of information (drug presence and activation) is superimposed on the traditional blood flow imaging, creating a multi-dimensional assessment of treatment effect that overcomes the limitations of single-modality imaging.

The patent employs periodic or sequential application of different light types rather than continuous simultaneous application. The treatment light, narrow band light, and excitation light are applied in a coordinated sequence or periodically, allowing the imaging system to capture images at appropriate intervals. This reduces cumulative energy exposure while maintaining the ability to assess multiple treatment parameters.

The imaging system dynamically adjusts the timing and intensity of different light applications based on treatment progression. The system can adaptively control when to apply treatment light versus when to capture images with narrow band or excitation light, optimizing energy usage while ensuring comprehensive treatment evaluation at critical time points.