Phototherapy Image Processing Device for Drug Accumulation Monitoring
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current phototherapy systems lack effective methods to confirm the accumulation and effectiveness of antibody-drugs in target regions during photoimmunotherapy, relying on fluorescence intensity which may not provide a clear indication of treatment progress.
Innovation Solution
An image processing device and system that generates white light images and absorption band light images, allowing for the display of absorption degree, enabling confirmation of antibody-drug accumulation and treatment progress without advancing the reaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescence intensity is used to confirm antibody-drug accumulation, then treatment progress can be monitored, but the indication is not clear and confirmation period is limited
Solution Approach 1:
The patent uses absorption band light images with distinct color representation to indicate antibody-drug accumulation. The absorption band light image displays regions with different absorption characteristics in different colors, providing clear visual indication of drug accumulation that overcomes the ambiguity of fluorescence intensity measurement.
Solution Approach 2:
The patent segments the imaging into two distinct components: white light images for anatomical reference and absorption band light images for functional information. This segmentation allows each imaging mode to optimize for its specific purpose, with absorption band light providing clear confirmation of drug accumulation without the limitations of fluorescence.
2Productivity
If the same wavelength band is used for both treatment and imaging, then treatment light can activate the drug, but the imaging period is limited by reaction advancement
Solution Approach 1:
The patent divides the light spectrum into distinct wavelength bands: white light (visible range) for imaging and near-infrared light for treatment. This segmentation allows simultaneous or sequential use of both imaging and treatment modes without interference, extending the imaging duration beyond the constraints of fluorescence decay.
Solution Approach 2:
The patent introduces absorption band light as an intermediary imaging modality that bridges between anatomical imaging and treatment activation. This intermediary allows monitoring of drug accumulation without directly triggering the photodynamic reaction, separating the imaging function from the treatment activation function.
3Loss of information
If multiple imaging modes are combined, then comprehensive information can be obtained, but system complexity increases
Solution Approach 1:
The patent implements a multi-functional imaging system where a single apparatus can capture both white light images and absorption band light images. The image processing device integrates both imaging modes and performs combined processing to generate composite images that display both anatomical and functional information, reducing overall system complexity while maintaining information completeness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables secure confirmation of antibody-drug accumulation and treatment progress over a longer period, ensuring accurate monitoring and potential for improved treatment outcomes by using distinct wavelength bands for imaging and treatment.
Implementation Method 1
The antibody-drug that is irradiated with the near-infrared light absorbs the light energy, undergoes molecular oscillation, and produces heat
Implementation Method 2
At that time, as a result of being subjected to excitation, the antibody-drug emits fluorescence
Implementation Method 3
an absorption band light emitter configured to emit an absorption band light made of a light having a wavelength band of Soret band which is absorbed by a drug accumulated in a target region for treatment
Data Source
AI summary
An image processing device includes a processor including hardware, the processor being configured to: generate a white light image based on a white light which is made of a light having a wavelength band of visible light range; generate an absorption band light image indicating an absorption degree of a light having a wavelength band of Soret band which is absorbed by a drug accumulated in a target region for treatment; and generate a display image based on the white light image and the absorption band light image.