Phthalate Ester Ion-Ratio Calibration for Mass Spectrometry

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Solution Overview

Problem

Existing mass spectrometry device calibration methods using PFTBA or DFTPP may not accurately reflect the suitability of the device for analyzing chemical substances like phthalate esters due to structural differences.

Innovation Solution

A method for evaluating a mass spectrometry device by performing mass spectrometry on an ester of phthalic acid, detecting multiple types of ions, and determining the device's suitability based on the intensity ratios of these ions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If PFTBA or DFTPP is used for mass calibration, then mass calibration can be performed, but the evaluation does not accurately reflect suitability for analyzing phthalate esters due to structural differences

Engineering Contradiction:

Improveaccuracy of device evaluationVSAvoidapplicability to target chemical substances

Core Design Contradiction:

Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical structure parameter of the calibration substance from PFTBA/DFTPP to phthalate ester, which has the same core structure as the target analysis objects. This parameter change ensures that the calibration substance's molecular structure matches the target substances, making the evaluation results accurately reflective of the device's actual analysis capability for phthalate esters

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent applies homogeneity by selecting a calibration substance (phthalate ester) that shares the same chemical structure and properties as the target analysis objects. This structural homogeneity ensures that the mass spectrometry device's performance evaluated using the calibration substance directly reflects its performance when analyzing the actual target substances, resolving the mismatch between calibration and actual analysis

Inventive Principle:

Principle #33Homogeneity

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method allows for accurate evaluation of the mass spectrometry device's suitability for analyzing chemical substances like phthalate esters, ensuring reliable analysis results.

Implementation Method 1

performing mass spectrometry of an ester of phthalic acid and detecting a plurality of types of ions produced by dissociation of the ester of phthalic acid

Methodology Applied

Scientific EffectIonization: Ionisation

Implementation Method 2

detecting a plurality of types of ions produced by dissociation of the ester of phthalic acid

Methodology Applied

Scientific EffectDissociation: Decomposition (biological)

Data Source

PatentUS12266517B2Method for evaluating mass spectrometry device, method for calibrating mass spectrometry device, analysis method, mass spectrometry device, and mass spectrometry reagent

Publication Date: 2025.04.01 SHIMADZU CORP

AI summary

A method for evaluating a mass spectrometry device includes: by a mass spectrometry device, performing mass spectrometry of an ester of phthalic acid and detecting a plurality of types of ions produced by dissociation of the ester of phthalic acid; and obtaining information concerning whether the mass spectrometry device is in a state suitable for analysis, based on a ratio of intensities of the plurality of types of ions detected.