Phthalimide Fungicide Composition with Acetic Acid Buffer

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Solution Overview

Problem

Formulating stable compositions of phthalimide fungicides, especially in high concentrations, is challenging due to their low solubility in water and maintaining pH above 4 during storage.

Innovation Solution

Incorporating an acetic acid-based buffer into the composition to stabilize the pH above 4, along with optional polyelectrolyte complexes, to create stable aqueous-based formulations including phthalimide fungicides.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If phthalimide fungicide is formulated in high concentration in water, then the effectiveness of the fungicide is improved, but the stability of the composition deteriorates due to low solubility and pH maintenance issues

Engineering Contradiction:
Improveconcentration of phthalimide fungicideVSAvoidstability of composition during storage
Core Design Contradiction:
Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent introduces an acetic acid-based buffer as an intermediary substance to mediate between the phthalimide fungicide and water. This buffer system (comprising acetic acid and acetate salts) maintains the pH within the optimal range of 4-6, preventing premature hydrolysis of the fungicide while allowing high concentration formulation. The buffer acts as a chemical mediator that enables the coexistence of high fungicide concentration and composition stability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent applies parameter changes by carefully controlling the pH parameter of the composition. By maintaining pH between 4-6 through the acetic acid buffer system, the patent optimizes both the solubility and stability of phthalimide fungicides. This parameter control prevents degradation while enabling high concentration formulation, directly resolving the contradiction between concentration and stability.

Inventive Principle:
Principle #35Parameter changes

2Device complexity

If phthalimide fungicide is suspended in water without buffer, then the formulation simplicity is improved, but the pH stability deteriorates causing degradation during storage

Engineering Contradiction:
Improveformulation complexityVSAvoidpH stability during storage
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The acetic acid-based buffer serves as a chemical intermediary that provides pH stability without significantly complicating the formulation. The buffer system comprises common substances (acetic acid and acetate salts) that can be easily incorporated into the aqueous suspension, maintaining reliability while adding minimal complexity to the formulation process.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If conventional buffers are used to maintain pH, then the pH control is improved, but the compatibility with phthalimide fungicide deteriorates

Engineering Contradiction:
ImprovepH controlVSAvoidincompatibility with phthalimide fungicide
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent selects acetic acid-based buffer specifically because its pH range (4-6) is compatible with phthalimide fungicide stability requirements. This parameter selection avoids the incompatibility issues that arise with stronger acids or bases, providing both effective pH control and chemical compatibility with the active ingredient.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The acetic acid-based buffer maintains the pH of the composition above 4 during storage, ensuring the stability and effectiveness of the phthalimide fungicide formulations.

Implementation Method 1

Incorporating an acetic acid-based buffer into the composition to stabilize the pH above 4

Methodology Applied
Scientific EffectBuffering:

Implementation Method 2

aqueous based composition comprising (1) phthalimide fungicide, (2) polyelectrolyte complex and (3) acetic acid-based buffer

Methodology Applied
Scientific EffectElectrostatic interaction: Ion Repulsion/Attraction

Data Source

PatentUS20250302036A1Phthalimide fungicide composition
Publication Date: 2025.10.02 ADAMA MAKHTESHIM LTD

AI summary

This invention relates to a composition comprising phthalimide fungicide and acetic acid-based buffer. The invention further relates to a process for preparing the composition according to the invention and to the use of said composition. The invention additionally relates to a method of treating a plant, or a part of a plant, against a pathogen, comprising contacting the plant, or part of the plant, with said composition.