Physiologic Time Series Forecasting Using Evolutionary Algorithms

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Solution Overview

Problem

Current hospital care systems fail to effectively predict and prevent patient deterioration due to fragmented care processes and limited sensitivity and specificity in existing predictive models, leading to unnecessary crises and resource misallocation.

Innovation Solution

A system and method for monitoring patients using evolutionary algorithms like particle swarm optimization and differential evolution to forecast physiologic parameters, providing a numerical probability of significant health status changes, and integrating data from multiple sources to facilitate timely intervention.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional EHR systems are used to store and document patient information, then information storage and documentation are achieved, but the system cannot actively predict future patient status or events

Engineering Contradiction:
Improveprediction accuracyVSAvoidprognostic information
Core Design Contradiction:
ReliabilityVSLoss of information

Solution Approach 1:

The system performs preliminary analysis of patient data using evolutionary algorithms to predict future clinical events before they occur. By continuously analyzing time-series physiological data and computing probability scores for deterioration, the system enables proactive intervention rather than reactive response, transforming the EHR from a passive repository to an active prediction tool.

Inventive Principle:
Principle #10Preliminary action

2Adaptability or versatility

If multiple providers are involved in patient care, then comprehensive care coverage is achieved, but fragmentation of responsibility reduces the ability to grasp clinical trends

Engineering Contradiction:
Improvecare coverageVSAvoidclinical context information
Core Design Contradiction:
Adaptability or versatilityVSLoss of information

Solution Approach 1:

The system merges data from multiple providers and sources into a unified predictive model. By integrating time-series physiological data, laboratory results, and clinical information from various providers into a single evolutionary algorithm framework, the system reconstructs the complete clinical picture that would otherwise be fragmented across multiple providers, enabling accurate prediction despite distributed care responsibilities.

Inventive Principle:
Principle #5Merging (Combining)

3Measurement precision

If more monitoring data is collected to improve prediction accuracy, then prognostic capability is enhanced, but system complexity and resource requirements increase

Engineering Contradiction:
Improveprediction precisionVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system changes the parameter of data processing by using evolutionary algorithms that can handle variable-length time-series data with different sampling frequencies. The algorithm adapts to different data densities and complexities by dynamically adjusting its analysis parameters, allowing accurate prediction without requiring a fixed complex infrastructure for data collection and processing.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS11972872B1Forecasting clinical events from short physiologic timeseries
Publication Date: 2024.04.30 CERNER INNOVATION INC
  • US11972872B1 patent drawing
  • US11972872B1 patent drawing
  • US11972872B1 patent drawing

AI summary

Systems, methods and computer-readable media are provided for monitoring patients and quantitatively predicting whether an event such as a significant change in health status meriting intervention, is likely to occur within a future time interval subsequent to computing the prediction. Medical data for a patient is collected from one or more different inputs and used to determine time series data. From this, a forecasted numerical value is computed for one or more physiologic parameters associated with the patient, which may be used to further monitor the patient and facilitate decision making about a need for intensified monitoring or intervention to prevent or manage physiologic or hemodynamic deterioration. An evolutionary algorithm, such as particle swarm optimization and/or differential evolution, may be used to determine the most probable value of the physiologic parameter(s) at one or more future times.