Physiological Condition Assessment via Biochemical Marker Vector Analysis
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Solution Overview
Problem
Current methods fail to effectively assess both the balance and overall dynamics of physiological conditions, particularly in monitoring therapeutic regimens and predicting fracture risk in osteoporosis, as they rely on cumbersome interpretation of biomarker concentrations and do not provide direct insight into bone turnover dynamics.
Innovation Solution
A method involving the measurement of first and second biochemical markers representing counteracting processes, presented as vectors, with logarithmic transformation to assess balance and magnitude, applicable to conditions like bone metabolism, cholesterol metabolism, and preeclampsia, allowing for accurate assessment of physiological conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If bone marker concentrations are measured and interpreted using conventional methods, then biomarker data can be obtained, but the interpretation becomes cumbersome and does not provide direct insight into bone turnover dynamics
Solution Approach 1:
The patent transforms bone marker concentrations into a coordinate system where the x-coordinate represents the balance between formation and resorption (log ratio of markers) and the y-coordinate represents the overall dynamics (log product of markers). This parameter transformation converts cumbersome concentration interpretation into intuitive geometric interpretation of position and orientation in 2D space.
Solution Approach 2:
The patent introduces a coordinate transformation as an intermediary step between raw bone marker measurements and clinical interpretation. This intermediary representation (balance coordinate and dynamics coordinate) mediates the complex relationship between multiple markers and provides direct insight into bone turnover dynamics.
2Loss of time
If BMD measurement is used to monitor treatment efficacy, then bone mineral density can be assessed, but changes are only detectable after 1 to 2 years of treatment
Solution Approach 1:
The patent uses bone markers as preliminary indicators of treatment response before actual BMD changes occur. By monitoring the balance and dynamics coordinates derived from bone markers, clinicians can predict treatment outcomes months in advance, performing the assessment action earlier than waiting for BMD changes.
Solution Approach 2:
The patent measures bone marker concentrations (which change rapidly) as a surrogate for BMD (which changes slowly). This partial measurement approach provides early indication of treatment efficacy by detecting changes in bone turnover dynamics before they manifest as measurable BMD changes.
3Loss of information
If multiple bone markers are measured to assess bone turnover, then comprehensive data on formation and resorption can be obtained, but the data presentation becomes complex and difficult to interpret
Solution Approach 1:
The patent projects multi-dimensional bone marker data onto a two-dimensional coordinate system where one axis represents balance (formation/resorption ratio) and the other represents dynamics (overall turnover magnitude). This dimensional transformation preserves comprehensive information while simplifying visualization and interpretation through geometric representation.
Solution Approach 2:
The patent combines multiple bone marker measurements into two integrated coordinates: the balance coordinate (log ratio) and the dynamics coordinate (log product). This merging consolidates complex multi-marker data into a unified two-coordinate framework that is easier to interpret while retaining all essential information.
Data Source
AI summary
The present invention relates to a method for assessing in vitro the balance and the overall dynamics of a physiological condition, wherein a) a first biochemical marker representing a first biochemical process associated with the physiological condition is measured, b) a second biochemical marker representing a second biochemical process associated with the physiological condition is measured, c) the ratio of the results obtained in (a) and (b) is calculated, d) the square root of the sum of the squared results obtained in (a) and (b) is calculated and, e) wherein the ratio calculated in (c) is used to assess the balance of the physiological condition and wherein the square root calculated in (d) is used to assess the overall dynamics of the physiological condition.