Physiological Indicator Detection via Systolic Artifact Correction

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Solution Overview

Problem

Existing methods for determining physiological parameters, such as fluid responsiveness, are inaccurate due to artifacts introduced by systolic arterial pressure variations during pressure cuff application, which affect respiratory pulse variation signals.

Innovation Solution

An apparatus and method that corrects respiratory pulse variation signals by identifying and modifying the systolic part of the signal, which corresponds to the time period when pressure passes the systolic arterial pressure, to remove artifacts and improve accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If pressure applied by the pressure cuff is continuously increased or decreased to measure pulse signal, then blood pressure can be determined non-invasively, but artifacts are introduced when the applied pressure passes the systolic arterial pressure

Engineering Contradiction:

Improveblood pressure measurementVSAvoidartifacts in respiratory pulse variation signal

Core Design Contradiction:

Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The respiratory pulse variation signal is segmented into different portions based on the applied pressure level. Specifically, signal portions where the applied pressure is within a threshold range of the systolic arterial pressure are identified and separated from the rest of the signal. This segmentation allows the artifact-contaminated portions to be processed differently, improving overall measurement accuracy.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The artifact-contaminated signal portions are extracted and removed from the respiratory pulse variation signal. By identifying signal portions where the applied pressure passes through the systolic arterial pressure and extracting these specific segments, the harmful artifacts are taken out from the overall signal, leaving a cleaner signal for physiological parameter determination.

Inventive Principle:

Principle #2Taking out (Extraction)

2Loss of information

If the respiratory pulse variation signal is used to determine physiological parameters like fluid responsiveness, then valuable clinical information can be obtained, but inaccuracies occur due to systolic arterial pressure variations

Engineering Contradiction:

Improvephysiological parameter accuracyVSAvoidindicator determination accuracy

Core Design Contradiction:

Loss of informationVSMeasurement precision

Solution Approach 1:

A threshold-based intermediary mechanism is introduced to mediate between the raw respiratory pulse variation signal and the final physiological parameter determination. The threshold, defined as a range around the systolic arterial pressure, acts as an intermediary criterion to identify and flag signal portions that are contaminated by systolic variations, allowing these to be excluded or corrected before parameter calculation.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The signal processing performs preliminary identification and marking of artifact-contaminated portions before the actual physiological parameter calculation. By预先 (in advance) identifying signal portions where applied pressure passes through systolic arterial pressure, the system prepares a cleaned or corrected signal dataset before computing indicators like pulse pressure variation or stroke volume variation, ensuring higher accuracy.

Inventive Principle:

Principle #10Preliminary action

3Productivity

If pressure cuff is used to monitor blood pulsations during respiratory cycles, then respiratory induced heart-lung interaction can be measured, but systolic arterial pressure variations cause measurement errors

Engineering Contradiction:

Improverespiratory cycle monitoringVSAvoidsignal accuracy

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The system dynamically adjusts the signal processing based on the real-time relationship between applied pressure and systolic arterial pressure. Rather than using a fixed processing approach, the method dynamically identifies signal portions where the pressure relationship indicates artifact contamination and applies appropriate corrections or exclusions only to those specific dynamic segments, preserving the reliability of the monitoring across varying respiratory cycles.

Inventive Principle:

Principle #15Dynamics

Data Source

PatentUS20250213120A1Apparatus for determining an indicator representative for a physiological parameter

Publication Date: 2025.07.03 KONINKLIJKE PHILIPS NV

AI summary

The invention relates to an apparatus for determining an indicator, which is representative for a physiological parameter of a patient like a fluid responsiveness parameter, based on a pulse signal. The apparatus determines a) a respiratory pulse variation signal (r0) corresponding to pulse variations caused by ventilation or respiration induced heart-lung interaction based on the pulse signal and b) a systolic part of the respiratory pulse variation signal, which corresponds to a time period in which an increasing or decreasing applied pressure passed the systolic arterial pressure of the patient and which therefore is prone to comprising an artifact. Moreover, the respiratory pulse variation signal is modified such that the determined systolic part of the respiratory pulse variation signal is corrected, wherein the indicator is determined based on the measured pulse signal and the modified respiratory pulse variation signal. This procedure allows for a more accurate determination of the indicator.