Physiological Temperature Organ Perfusion System
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Solution Overview
Problem
Current organ preservation techniques are inadequate for maintaining organs in a viable state for extended periods, leading to ischemia and tissue injury, limiting the time available for transplantation and making suitable organs scarce.
Innovation Solution
Development of improved perfusion systems and solutions that maintain organs in a functioning state at physiological temperatures, using energy sources, amino acids, cardio stimulants, and electrolytes to minimize ischemia and reperfusion injury, and include drug delivery systems for enhanced preservation and patient care.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If current preservation techniques (cryopreservative methods) are used to cool the organ below physiological temperatures, then the organ can be preserved for extended periods, but the organ suffers from ischemia and tissue injury due to lack of energy replenishment
Solution Approach 1:
The patent changes the temperature parameter from cryogenic (below 25°C) to physiological temperature (37°C), fundamentally altering the preservation approach. This parameter change enables the organ to maintain metabolic function while being preserved, eliminating ischemia and tissue injury associated with cold storage
Solution Approach 2:
The patent enables the organ to serve itself by providing it with all necessary components for metabolic function (energy sources, amino acids, vitamins, electrolytes, hormones). The organ autonomously maintains its own viability through these self-replenishing nutrients without requiring external intervention or cooling
2Duration of action of stationary object
If preservation solutions with high molecular weight impermeants are used to maintain the organ at low temperatures, then the organ can be preserved, but harmful components are introduced to the organ
Solution Approach 1:
The patent extracts and eliminates the harmful high molecular weight impermeants from the preservation solution, replacing them with beneficial physiological components. This removal of harmful substances prevents organ damage while maintaining preservation effectiveness
Solution Approach 2:
The patent creates a composite preservation solution containing multiple beneficial components (energy sources, amino acids, vitamins, electrolytes, hormones) that work synergistically to maintain organ viability at physiological temperature, replacing the single-component cryopreservative approach
3Loss of time
If the organ is preserved for extended periods beyond three to four hours, then more time is available for transplantation, but the organ becomes unviable due to ischemia and tissue injury
Solution Approach 1:
The patent ensures continuous useful action by providing uninterrupted metabolic support through the preservation solution. Energy sources, amino acids, and other nutrients are continuously supplied to maintain cellular function, allowing the organ to remain viable for extended periods without degradation
Data Source
AI summary
The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.