Phytocannabinoid Nanoemulsion for Bioavailability and Immune Modulation
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Solution Overview
Problem
Existing cannabinoid-based treatments face limitations in administration due to first-pass hepatic metabolism, low bioavailability, and difficulty in formulating high concentrations for intravenous, oral, and topical routes, while chemotherapy adversely affects immune function in cancer patients.
Innovation Solution
Development of a nanoemulsion comprising phytocannabinoid isolates, terpenes, olive oil, and surfactants, formulated for topical, oral, or sublingual administration, which stabilizes the immune system and enhances immune function in chemotherapy patients, and can be administered in combination with other therapies.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cannabinoid-based treatments are administered via conventional routes (oral, intravenous, topical), then treatment can be provided, but first-pass hepatic metabolism reduces bioavailability and formulation of high concentrations is difficult
Solution Approach 1:
The patent employs an intermediary formulation system (nanoemulsion) that mediates between the cannabinoid substance and the body's metabolic systems. This nanoemulsion formulation protects the cannabinoids from first-pass hepatic metabolism while maintaining high bioavailability, effectively resolving the contradiction between administering treatment and avoiding metabolic degradation.
Solution Approach 2:
The patent changes the physical and chemical parameters of cannabinoid delivery by transitioning from conventional formulations to nanoemulsion technology. This parameter change (particle size, emulsion structure) fundamentally alters how cannabinoids are processed by the body, eliminating first-pass metabolism issues while maintaining high concentrations and bioavailability.
2Reliability
If chemotherapy is administered to treat cancer, then tumor can be treated, but immune function is adversely affected
Solution Approach 1:
The patent converts the harmful effect of chemotherapy on the immune system into a beneficial opportunity. By administering cannabinoids that specifically target CB2 receptors on immune cells, the treatment transforms the immunosuppressive state induced by chemotherapy into an enhanced immune response, turning the harmful side effect into a therapeutic advantage.
Solution Approach 2:
The patent applies local quality by targeting specific cell types (CB2-expressing cells including immune cells, cancer cells, and stem cells) with different effects. While chemotherapy provides broad anti-tumor activity, the cannabinoid treatment provides localized immune modulation and protection, creating different functional qualities in different tissue environments.
3Quantity of substance
If high concentrations of cannabinoids are formulated for administration, then treatment efficacy can be improved, but formulation difficulty increases
Solution Approach 1:
The patent uses composite material technology by creating a nanoemulsion system that combines multiple components (cannabinoids, lipids, surfactants, and co-emulsifiers) in a stable, manufacturable formulation. This composite approach enables high concentrations to be achieved while maintaining formulation stability and ease of manufacture through standardized nanoemulsion processing techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanoemulsion composition effectively stabilizes immune cell populations, synergizes with chemotherapy and immunotherapy, reducing tumor burden and prolonging survival in cancer patients by enhancing immune response and tumor surveillance.
Implementation Method 1
a nanoemulsion comprising one or more phytocannabinoid isolates and at least four terpene isolates
Data Source
AI summary
Compositions comprising one or more phytocannabinoids and methods of use thereof for treatment of cancer, immune modulation, and protecting the immune system are provided.