Phytocannabinoid Topical Composition for Skin Lesion Reduction
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Solution Overview
Problem
Current treatments for atopic dermatitis, urticaria, and skin damage from radiation or UV exposure are inadequate in providing long-lasting anti-inflammatory effects and deep skin hydration, often relying on synthetic materials that can cause side effects or be ineffective.
Innovation Solution
A topical composition combining phytocannabinoids from Cannabis sativa with Calendula officinalis extract, which includes Cannabidiol (CBD), Cannabidiolic acid (CBDA), Cannabivarin (CBV), and Cannabigerol (CBG), along with Calendula flower extract, to create an anti-inflammatory, antioxidant, and bactericidal effect, promoting skin hydration and reducing inflammatory and oxidative damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If synthetic anti-inflammatory materials are used, then inflammatory effects are reduced, but side effects and cytotoxicity increase
Solution Approach 1:
The patent changes the chemical composition parameters by using plant-derived phytocannabinoids (CBD, CBDA, CBC, CBG) instead of synthetic anti-inflammatory materials. This parameter change maintains anti-inflammatory efficacy while eliminating synthetic cytotoxicity and side effects, as demonstrated by the biocompatibility and safety profile of the natural compounds in the composition.
Solution Approach 2:
The patent creates a composite material system combining multiple phytocannabinoids (CBD, CBDA, CBC, CBG) with specific concentration ratios. This composite approach synergistically enhances anti-inflammatory effects while maintaining safety, as the combination of different cannabinoid compounds provides broader therapeutic activity compared to single synthetic agents.
2Object-affected harmful factors
If current treatments are used, then skin lesions are treated, but long-lasting anti-inflammatory effects and deep skin hydration are insufficient
Solution Approach 1:
The patent incorporates ingredients that perform preliminary hydration and anti-inflammatory action before lesion development or flare-ups. The composition pre-hydrates the skin barrier and suppresses inflammatory pathways in advance, creating a reservoir of protective effect that extends beyond immediate lesion treatment, thereby achieving long-lasting benefits.
Solution Approach 2:
The patent formulates a composition with multiple active compounds that provide continuous anti-inflammatory and hydrating action. The combination of phytocannabinoids with different pharmacokinetic profiles ensures sustained therapeutic effect, while the emollient base provides continuous skin barrier support and hydration, eliminating the need for frequent reapplication and extending duration of action.
3Object-affected harmful factors
If synthetic materials are used, then treatment effectiveness is achieved, but skin hydration and biocompatibility are compromised
Solution Approach 1:
The patent extracts and utilizes only the beneficial phytocannabinoid compounds (CBD, CBDA, CBC, CBG) from the Cannabis sativa plant, separating them from potentially harmful synthetic materials. This extraction approach maintains treatment effectiveness through the isolated active compounds while eliminating synthetic cytotoxicity, improving biocompatibility and safety for sensitive skin conditions.
4Object-affected harmful factors
If complex treatment regimens are used, then multiple symptoms are addressed, but treatment complexity and potential for irritation increase
Solution Approach 1:
The patent develops a universal topical composition that simultaneously addresses multiple symptoms including inflammation, hydration, oxidation, and bacterial contamination. The multi-component phytocannabinoid formulation provides broad-spectrum therapeutic activity through a single application, eliminating the need for multiple separate treatments and reducing overall treatment complexity while managing diverse skin conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces skin lesions and inflammation, enhances skin hydration, and provides a soothing effect without using synthetic cytotoxic materials, offering a synergistic approach to treat atopic dermatitis, urticaria, and radiation-induced skin damage.
Implementation Method 1
cyclooxygenases (COX1 and COX 2) to produce regulatory molecules eicosanoids: prostaglandins or thromboxanes. The second possibility for metabolism of the arachidonic acid is the pathway controlled by lipoxygenase (LOX)
Implementation Method 2
oxidation and skin inflammation... imbalance between ROS and antioxidants can lead to an elevated oxidative stress level
Implementation Method 3
enhances skin hydration... reduction of skin lesions and inflammation, enhances skin hydration
Data Source
AI summary
Disclosed is a method of treatment using a topical composition including essential sombination of synergistically acting phyto-active materials, non-psychotropic phtocannabinoids from the plant of Cannabis sativa: Cannabidiol, Cannabidiolic acid, Cannabivarian Cannabigerol in combination with extract of Calendula flower and the formulation of the base to ensure the features of anti-inflammation, anti-oxidation, emollient, and bactericidal components. The topical composition is an emollient dedicated for reduction of skin lesions caused by atopic dermatitis, urticaria, radiotherapy and UV induced skin damage and acne. In addition, the topical composition could reduce secretion of fats, facilitate deep skin hydration, reduce pores, and exert soothing effects.